STRUCTURE OF THE THYROID GLAND IN RATS WITH DIFFERENT STRESS TOLERANCE DURING CEREBRAL HYPOPERFUSION

Abstract

Objective - to study the structural features of the thyroid gland in animals with different stress tolerance during cerebral hypoperfusion. Material and methods. The microstructure of the thyroid gland was studied in 104 rats with different levels of stress tolerance verified in open field test. Thyrocytes height, follicle diameter, areas of single islands of the interfollicular epithelium, relative proportion of perifollicular blood capillaries and average area of mast cell cytoplasm were measured on the thyroid gland slides. Results. Animals with high stress tolerance, compared with animals with low stress tolerance, had significant differences in the structure of the thyroid gland: a greater height of the thyroid epithelium and a greater specific area of blood capillaries as well as larger average area of mast cells of the thyroid gland. Cerebral hypoperfusion was accompanied by the activation of folliculogenesis, a decrease of mast cell area and an increase in the perifollicular capillary blood volume. In animals with a high level of stress tolerance a decrease in the height of thyrocytes in the early periods switched to its growth on the 35th day of the experiment, and activation of folliculogenesis was registered. Conclusions. The animals stress tolerance level is associated with the structural parameters of the thyroid gland. During cerebral hypoperfusion, groups with high and low stress tolerance have different dynamics and severity of compensatory changes.

Keywords

thyroid gland / stress resistance / cerebral hypoperfusion / experiment

RIGHTS & PERMISSIONS

Krishtop V.V., Rumyantseva T.A., Agadzhanova L.S.