NEUROPEPTIDE Y-ERGIC NEURONS OF THE SMALL INTESTINE IN POSTNATAL ONTOGENESIS

Abstract

Objective - to demonstrate the localization, percentage and morphometric characteristics of NPY-immunoreactive (IR) neurons in the intramural ganglia of the myenteric (MP) and submucous neural plexus (SP) of the small intestine in rats of different age groups. Material and methods. The work was performed on 1-, 10-, 20-, 30-, 60-day-old and 2-year-old rats using immunohistochemical methods. Results. NPY-IR neurons were detected in the small intestine from the moment of birth and throughout all studied age periods. In the intramural ganglia of the MP, their number was very small and did not change significantly during ontogenesis. In the SP, NPY-IR neurons were detected in large numbers in newborns; the maximal number of the neurons was observed at 20-30 days. The average cross-sectional area of the NPY-IR cells in the SP was significantly larger than such area of immunonegative neurons in 10-day-old and older rats. Conclusions. Thus, neuropeptide Y is fairly common in various parts of the autonomic nervous system, including sympathetic, parasympathetic and metasympathetic, and plays an important role in the processes of age-related neuronal development.

Keywords

neuropeptide Y / autonomic nervous system / enteric ganglia / small intestine / ontogenesis

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RIGHTS & PERMISSIONS

Maslyukov P.M., Vyshnyakova P.A., Aryaeva D.A., Budnik A.F.