Comparative analysis of morphological changes in renal tissue under the influence of light desynchronosis

Abstract

AIM: To compare morphological changes that occur in renal tissue, as a result of exposure to various models of light desynchronosis.

MATERIAL AND METHODS: This study was conducted on 48 white rats. Three experimental groups were exposed to light for 21 days. The LL (0:24) model was studied in the first group, while the LD 18:6 and 12:10 models were studied in the second and third groups, respectively. The control group was kept in natural conditions all through the experiment.

The animals were placed under anesthesia with a combination of Telazol (ZoetisInc, USA) and Xylanit (Nita-farm, Russia). Afterward, their right kidney was removed. The samples obtained were prepared according to the standard method. Statistical processing was performed using the package of applied statistical programs "STATISTICA 10" (StatSoft ®, USA).

RESULTS: Morphological disorders of the renal tissue were observed in the three experimental groups. In the first experimental group, there was a significant segmentation of the glomeruli, accompanied by dystrophic changes in the renal tubules. In the second experimental group, glomerular segmentation was more pronounced. In the renal tissue of animals of the third experimental group, the disorders were highly observable, and the sclerotized segment is noted. Changes in morphometric indicators were significant across all experimental groups.

CONCLUSION: Desynchronosis harms the renal tissue by causing changes in its morphology. The most significant disorders characterized by sclerosis were observed in the kidneys of animals in the third experimental group.

Keywords

morphofunctional state of kidneys / morphometric criteria / jet lag

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RIGHTS & PERMISSIONS

Zlobina O.V., Ivanov A.N., Milashevskaya T.V., Seryogina V.Y., Bugaeva I.O.