Embryonic development of the cruciate complex of the human knee joint: I. Anlage and primary differentiation
A. N. Makarov , S. P. Mironov , M. P. Lisitsyn , S. V. Saveliev , V. B. Nikitin , V. I. Gudimova
N.N. Priorov Journal of Traumatology and Orthopedics ›› 2001, Vol. 8 ›› Issue (1) : 57 -61.
Embryonic development of the cruciate complex of the human knee joint: I. Anlage and primary differentiation
Twenty six human abortive embryons (6-13.5 weeks of prenatal development) were for the study of cruciate complex embryonal differentiation. Serial histological mounts (8—12 mkm) were prepared from leg fragments with knee joint. Mallory, hematoxylin-eosine and antibody for collagen III were used for staining. Human cruciate complex appears in embryons at 6-6.5 weeks of development. It differentiates from the mesenchyme lying between tibia and fibula. Starting from 8.5-9 weeks the anterior and double-component posterior ligaments, which begin to vascularize on the surface, can be distinguished. At the age of 13 weeks both components of posterior ligament fuse and the complex itself starts to vascularize throughout the whole mass.
complex of cruciate ligaments of the knee joint / artificial graft / immunohistochemical studies
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