Prevention of Thromboembolic Complications afterSurgical Treatment for Lower Extremity BoneFractures: Experience in Rivaroxaban Use in ClinicalPractice

Abstract

Comparative evaluation of rivaroxaban (main group, n=37) and enoxaparin (control group, n=29) safety in thromboprophylaxis at closed lower extremity bone fractures treatment was performed. All patients were operated on at terms from 8 to 12 day after injury using external fixation devices. The volume of intra- and perioperative blood loss in the groups did not differ significantly ( p >0.05). The rate of symptomatic thromboembolic complications, i.e. calf deep vein thrombosis confirmed by clinical data, was significantly lower in patients from the main group (2.7%) as compared to the control group (6.8%; p <0.05). No one case of clinically important pulmonary embolism was diagnosed. The obtained data showed that in comparable with enoxaparin clinical efficacy for prevention of venous thromboembolic complications the use of rivaroxaban ensured the better clinical safety, convenience of intake and completeness of prophylaxis scheme without the change of pharmacological support.

Keywords

lower extremity bone fractures / venous thromboembolic complications / thromboprophylaxis / transosseous osteosynthesis / rivaroxaban / low molecular weight heparins

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