Modeling of a Different Volume Spinal Cord Injury in Rats and Methods for Evaluation of Lost Functions Restoration
S. P Mironov , S. V Kolesov , G. A Stepanov , M. L Sazhnev , S. P Gubin , Yu. V Ionin , V. G Motin , A. A Panteleev
N.N. Priorov Journal of Traumatology and Orthopedics ›› 2015, Vol. 22 ›› Issue (3) : 73 -77.
Modeling of a Different Volume Spinal Cord Injury in Rats and Methods for Evaluation of Lost Functions Restoration
The method for modelling of a different volume spinal cord injury to study potentialities for its regeneration is presented. The work was performed on 80 laboratory rats divided into 5 groups according to the volume of inflicted injury. Original instrument with restrictors for the infliction of the accurate and measured by volume spinal cord injuries was elaborated. The degree of function restoration was evaluated by the results of visual assessment of the movements in animals’ hind paws, records of induced potentials of the cerebral cortex region and by BBB scale. In every separate group the obtained indices were distributed uniformly that indicated justifiability and reproducibility of the elaborated model of incomplete spinal cord injury.
spinal cord / injury / motor activity / injury / motor activity / induced potentials
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