Experimental Evaluation of Osteoinduction of Recombinant Bone Morphogenic Protein (rhBMP-2) of Native Production Fixative on Biocomposite or Bone Matrix

S P Mironov; A L Gintsburg; N A Es'kin; V G Lunin; N S Gavryushenko; A S Karyagina; Vladimir Valentinovich Zaytsev; S P Mironov; A L Gintsburg; N A Es'kin; V G Lunin; N S Gavryushenko; A S Karyagina; V V Zaytsev

doi:10.17816/vto201017438-44

N.N. Priorov Journal of Traumatology and Orthopedics ›› 2010, Vol. 17 ›› Issue (4) : 38 -44. DOI: 10.17816/vto201017438-44

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Experimental Evaluation of Osteoinduction of Recombinant Bone Morphogenic Protein (rhBMP-2) of Native Production Fixative on Biocomposite or Bone Matrix

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Data on experimental evaluation of osteoinduction of recombinant bone morphogenic protein of native production fixative on xenogenic demineralizated bone matrix or collagen-calcium-phosphate biocomposite material. Evaluation was performed using experimental model of end-to-end osteosynthesis of diaphyseal femur fragments by external fixative device in Wistar rats. Roentgenologic examination, study of autopsy material and evaluation of bone consolidation strength using biomechanical twisting test showed high osteoinduction of rhBMP-2 containing biocomposites.

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recombinant bone morphogenic protein / osteoinduction / end-to-end os-teosynthesis / experimental model

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S P Mironov, A L Gintsburg, N A Es'kin, V G Lunin, N S Gavryushenko, A S Karyagina, Vladimir Valentinovich Zaytsev, S P Mironov, A L Gintsburg, N A Es'kin, V G Lunin, N S Gavryushenko, A S Karyagina, V V Zaytsev. Experimental Evaluation of Osteoinduction of Recombinant Bone Morphogenic Protein (rhBMP-2) of Native Production Fixative on Biocomposite or Bone Matrix. N.N. Priorov Journal of Traumatology and Orthopedics, 2010, 17(4): 38-44 DOI:10.17816/vto201017438-44

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