Some Aspects of Reparative Osteogenesis Optimization in Long Bone Fractures
Evgeniy Yul'evich Maslennikov , I I Taranov , T M Al'-Naddzhar , I B Vovchenko , E Yu Maclennikov , I I Taranov , T M Al-Naddzhar , I B Vovchenko
N.N. Priorov Journal of Traumatology and Orthopedics ›› 2010, Vol. 17 ›› Issue (3) : 51 -54.
Some Aspects of Reparative Osteogenesis Optimization in Long Bone Fractures
The aim of the examination was to study the influence of some proteolytic enzymes (cathepcin-D, neutral proteinaze of serine group) upon formation of bone regenerate in fractures. There were 138 patients with bone fractures: 80 fractures were fresh, 38 - nonunited, 20 - nonconsolidated. Periosteal and transfragmental tissues were studied. Those materials were obtained during osteosynthesis that was performed at different terms after trauma. Results obtained allowed to make a suggestion that acid and neutral peptide-hydrolases influence the osteosynthesis and degradation of macromolecular components of bone organic matrix during reparative osteogenesis. That allowed detecting the new ways for optimization of reparative processes in fractures.
fractures / regeneration / proteolysis
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