Evaluation of Analgetic Effect of Dexalginum 25 (Dexketoprofen) in Traumatology and Orthopaedics

Abstract

Clinical testing of analgetic effect and safety of nonsteroid anti-inflammatory drug dexalginum 25 was conducted in 45 patients with injuries and pathology of loco-motor system. Control group (49 patients with similar pathology and manifestation of pain syndrome) was treated by opium analgetic tramadol retard. It was shown that dexalgin 25 in therapeutic doses possessed analgetic effect in acute and chronic pains of various severity. The highest efficacy of the drug was noted in acute pains of medium and moderate severity. In patients with very severe pains dexalgin 25 allowed to decrease narcotic analgetics dose by 2 times. Dexalgimun 25 provided chronic pain relief only within the period of its use. Side effect were noted 2.7 times rarely in comparison to tramadol retard and such effect were less marked. Rate «favor-risk* of unsteroid anti-inflammatory drug dexalginum 25 was better than in opium analgetic tramadol retard.

References

[1] Cashman J., McAnulty G. //Drugs. - 1995. - Vol. 49. P. 51-70.

[2] Cherng С.Н., Wong C.S., Ho S.T. //Acta Anaest. Sinica. 1996. - Vol. 34. - P. 81-88.

[3] Gebnart G.F., McCormack K.J. //Drugs. - 1994. - Vol. 47, Suppl. 5. - P. 1-47.

[4] Eschailer A., Picrd P. //Analgesiques. La revue du praticien. -2000. - Vol. 50. - P. 908-910.

[5] Insei P.A. // Pharmacological base of therapeutic /Eds. J.G. Hardman, A.G. Gilman, L.E. Limbird. - 9th ed. - New York, 1996. - P. 617-657.

[6] Konttinen Y.T., Kemppinen P., Segerberg M. et al. //Arthr. Rheum. - 1994. - Vol. 37. - P. 965-982.

[7] Kubler U., Metscher В., Jahnel-Kracht H. //Schmerz. - 1999. - Suppl. 1. - S. 81.

[8] Preston K.L., Jasinski D.R., Testa M. //Drug. Alcjhol. Depend. - 1991. - Vol. 27. - P. 7"17.

[9] Richter W., Barth H., Flohe L. et al. //Arzneimittelforsc. Drug Res. - 1985. - Bd 35. - S. 1742-1744.

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