Peripheric primitive neuroectodermal tumor (Askin)
A. N. Makhson , A. S. Burlakov , I. V. Kuzmin , K. K. Pugachev , M. I. Popov
N.N. Priorov Journal of Traumatology and Orthopedics ›› 1999, Vol. 6 ›› Issue (2) : 54 -62.
Peripheric primitive neuroectodermal tumor (Askin)
The case of preoperative diagnosis of peripheric primitive neuroectodermal tumor (pPNET) of the chest with damage of body sternum in 21-year-old patient is presented in Native literature for the first time. CT and echography data as well as serum tumor-markers level are given. The detection of tissue-markers and electronic microscopy data are the most reliable diagnostic methods. However clinical and routine morphologic examinations are important as well. Our patient received neoadjuvant chemotherapy followed by chest resection and plasty by osseous-musculocutaneous flap on vascular pedicle. Efficacy of polychemotherapy with vincristine, cyclophosphan, farmorubicin and platidiam is proved. Nine months after operation no tumor relapse and metastasis were observe. In spite of relatively low sensitivity of pPNET to cytostatic drugs, combined treatment with neoadjuvant is the most justified. Original method for the plasty of chest defect with no application of artificial materials provides favourable conditions for wound healing with good and satisfactory cosmetic outcomes.
Peripheral primitive neuroectodermal tumor / Askina
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