Use of Clexane for the Preservation of Thromboembolic Complications Following Hip Replacement Surgery
N. I. Arzhakova , V. A. Novoseltseva , E. E. Brovkina , E. E. Biryukova
N.N. Priorov Journal of Traumatology and Orthopedics ›› 1998, Vol. 5 ›› Issue (3) : 40 -46.
Use of Clexane for the Preservation of Thromboembolic Complications Following Hip Replacement Surgery
In 28 patients (27 hip and 1 knee replacement) Clexane was used in dose 40 mg/day to prevent the development of complications. Clexane («Rhone-Poulenc Rorer», France) is a low molecular weight heparin. The volume of intra- and postoperative blood loss, hemoglobin level, platelets count, coagulogram were analysed in all patients. Efficacy of clexane was evaluated by the absence of clinical signs of deep veins thrombosis and pulmonary embolism, the safety was evaluated by the absence of clinical signs of bleeding. Clexane was determined to give effect on the system of blood coagulation and platelets count (tendency to thrombocytopenia). In no one case clinical signs of deep veins thrombosis and pulmonary embolism as well as the signs of hemorrhagic events were detected.
clexane / thromboembolic complications / hip arthroplasty / heparin
| [1] |
Баркаган З.С. //Тер. архив. — 1993. — N 10. — С. 77—82. |
| [2] |
Добротворская Т.Е., Медынцев Н.М., Швец О.И. //Московский мед. журн. — 1997. — Май. — С. 33—37. |
| [3] |
Савельев В.И., Яблоков В.Г., Кириенко А.И. Тромбоэмболии легочных артерий. — М., 1979. |
| [4] |
Bergqist D., Lowe G.D.O., Berstadt A. et al. //Br. J. Surg. — 1992. — Vol. 79. — P. 495—498. |
| [5] |
Borris L., Lassen M., Jensen H. et al. //Int. Clin. Pharmacol. Ther. — 1994. — Vol. 32, N 6. — P. 262—268. |
| [6] |
Consensus stafement. Prevention of venous thromboembolism: Guidelines according to scientific evidence //Int. Angiol. — 1997. — Vol. 16, N 1. — P. 3—38. |
| [7] |
Gazzaniga G.M. et al. //Int. Surg. — 1993. — Vol. 78. — P. 271—275. |
| [8] |
Kakkar V.V., Spindler J., Flute P.T. et al. //Lancet. — 1972. — N 2. — P. 101—108. |
| [9] |
Leizorovicz A. et al. //BMJ. — 1992. — Vol. 305. — P. 913—920. |
| [10] |
Levine N., Hirsch G., Gent M. et al. //Ann. Int. Med. — 1991. — Vol. 114. — P. 545—551. |
| [11] |
Meyer M., Samama M.D. //Clin. Lab. Med. — 1995. — Vol. 15, N 1. — P. 119—123. |
| [12] |
National Institute of Health Consensus Development Panel: Prevention of venouse thrombosis and pulmonary embolism //JAMA. — 1986. — Vol. 256, N 6. — P. 744—749. |
| [13] |
Nilsson P.E., Fredin H., Bergqist D. et al. //Orthopedics. — 1997. — Vol. 20, Suppl. 2 — P. 22—25. |
| [14] |
Planes A., Vochelle N., Fagola M. et al. //Acta Chir. Scand. — 1990. — Suppl. 556. — P. 108—115. |
| [15] |
Planes A., Vochelle N., Darmon J. et al. //Lancet. — 1996. — Vol. 348 (9022). — P. 224—228. |
| [16] |
Salzman E.W., Hirsh I. //Basic Principles and Clinical Practice. — 2-d ed. — Philadelphia, 1987. — P. 1252—1265. |
| [17] |
Spiro T.E., Jonson G.J., Christie M.E. et al. //Ann. Int. Med. — 1994. — Vol. 121, N 2. — P. 81—89. |
| [18] |
Turpie A.G.J., Levine M.N., Hirsh J. et al. //Engl. J. Med. — 1986. — Vol. 315, N 15. — P. 925—929. |
Eco-Vector
/
| 〈 |
|
〉 |
PDF
