Neutron-Activative Analysis of Bone Tissue in Children with Rickets-Like Diseases

Abstract

In 20 children with genetic caused vit.D metabolism disturbance and 13 conditionally healthy children (control group) 29 chemical elements (main elements — Ca, Cl, K, Mg, P and microelements — Al, Ag, Co, Cr, Cs, Fe, Hg, Rb, Sb, Sc, Se, Sr, Tc, Zn) were evaluated in bioptates of the upper flaring portion of the ilium using neutro-activative analysis. In test group the study was performed twice: before treatment and 1 year after the treatment course. Madication consisted of high doses of vit.D and its active metabolites, drugs containing Ca, P as well as vit.A, vit.E and group of vit.B. Bone tissue of patients had marked deficit of main elements, especially Mg, and the content of most of microelements including Zn, Sr, Mn was higher than in control group. In 1 year after the beginning of treatment the mineral bone content in the test group increased almost to norm. However the remaining Mg deficit and high content of some microelements allow to assume certain inferiority of bone tissue and indicate the necessity of further treatment.

Keywords

neutron activation analysis / biopsy / bone tissue / rickets-like diseases / osteomalacia

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