Patho- morphologic Peculiarities of the Stages of Osteitis Deformans Develkopment (Paget’s Disease)

Abstract

Pathomorphologic examinations of the biopsy and operative specimens were performed in 39 patients with osteitis deformans who underwent surgery at the department of Bone Pathology in Adults (CITO) during the period fron 1958 to 1995. On the basis of the personal and literature data the authors underlined three stages of the osteitis deformans development that differed by the pathologic peculiarities and activity of the pathologic process: 1st stage - stage of osteolysis characterizing by marked bone resorption; 2nd stage - stage of remodelling characterizing by the combination of disturbance process and formation of new bone; 3rd stage - stage of the attenuation of pathologic process during which the resorption and new bone formation stopped. Application of drugs that inhibit bone tissue resorption is the most expedient in the 2nd and especially in the 1st stage of the disease.

Keywords

osteosis / Paget's disease / osteolysis / bone resorption / remodeling

References

[1] Климова М.К. //Вопросы рентгенологии и радиологии. — М., 1959. — С. 149—154.

[2] Косинская Н.Е. //Фиброзные дистрофии и дисплазии костей. — Л., 1973. — С. 62—127.

[3] Русаков А.В. //Болезни костной системы и суставов. — М., 1959. — С. 386—402.

[4] Jaffe H.L. Metabolic, Degenerative and Inflammatory Disease of Bones and Joints. — Philadelphia, 1972.

[5] Krane S.M. //Clin. Orthop. — 1977. — Vol. 127. — P. 24—36.

[6] Milgram J.W. //Ibid. — 1977. — Vol. 127. — P. 43—54.

[7] Reginster J.Y., Lecart M.P., Deroisy R. et al. //Ann. Rheum. Dis. — 1993. — Vol. 52. — P. 54—57.

[8] Ryan P.J., Gibson T., Fogelman I. //J. nucl. Med. — 1992. — Vol. 33. — P. 1589—1593.

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