The inertness of lymphocitic Fc-receptors under effect of prostaglandins and isoproterenol and alteration of lipid metabolism in children with insulin-dependent diabetes mellitus

Abstract

The study was organized to examine lipid spectrum of blood lymphocytes in children with insulin-dependent diabetes mellitus. The capacity of Fc-receptors of lymphocytes to respond to effect of prostaglandins and isoproterenol having modulating characteristics was also examined. The sampling included 18 children with insulin-dependent diabetes mellitus in decompensation phase aged from 7 to 15 years. The control group consisted of 12 healthy children of the same age. The examination of surface receptors to Fc-fragments IgG was implemented using reaction of EA-rosetting. The lipid and phospholipid spectrum of lymphocytes were analyzed using technique of thin-layer chromatography of lipids. The established “areactivity” of surface Fc-receptors of lymphocytes is related to alteration of lipid composition of membranes of lymphocytes. In this connection, it is possible to expect that other receptors fixed on the membrane will faintly react to effect of modulators similar to prostaglandins and isoproterenol.

Keywords

children / diabetes mellitus / lipid metabolism / Fc-receptors of lymphocytes

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