The indicators of lipoprotein metabolism and their association with psycho-emotional factors in healthy individuals

Abstract

The article deals with studying indicators of lipoprotein metabolism in relationship with psycho-emotional factors in healthy individuals. The sampling included 107 healthy individuals of able-bodied age from organized population (46 males and 61 females) with mean age made up to 43.4±10.8 years. All examined individuals were applied clinical psychological study using such questionnaires as Spielberger-Khanin test, Center for Epidemiological Studies Depression cale (USA), visual analogue scale-modified version of Dembo-Rubinstein technique, social frustration scale, Holmes-Rahe social adaptation test. To analyze indicators of lipidogram venous blood was taken. The most of lipid indicators were higher in individuals with clinically significant levels of depression, personal anxiety and accumulated stress independently of gender. In female group statistical reliability was reached by mean indicators of total cholesterol, cholesterol lipoproteins of low density, cholesterol not bounded with lipoproteins of high density. In male group statistical reliability was reached by ratio apoB/apoA. The most prevalence of dislipoproteinemia was established in male group and at that reliable differences were reached by rate of hypertriglyceridemia and higher level of apoB100. The rate of personal anxiety and clinically significant stress measured by Holmes-Rahe scale was reliably higher in group of examined females and made it up to 75% and 36% correspondingly. In both groups association of psycho-emotional factors with indicators of lipid profile was established. At that, in males the study detected an independent relationship between both of level of personal anxiety and social frustration and apoproteins and between cumulated stress and level of cholesterol not bound with lipoproteins of high density as well. In females association of accumulated stress according Holmes-Rahe scale with level of total cholesterol and atherogenity index was established. The study data indicate at necessity to determine means of development of complex primary prevention of stress-induced disorders of lipoprotein metabolism with consideration for psycho-emotional factors and gender characteristics of their effect.

Keywords

indicator / lipid metabolism / psycho-emotional factor / gender differences

References

[1] Жаворонкова Е.Ю. Оценка влияния иАПФ на качество жизни и психологический статус пациентов с артериальной гипертензией. Верхневолжский медицинский журнал. 2006; 34(4): 41-4.

[2] Бурячковская, Л.И., Полякова Е.О., Сумароков А.Б. Влияние депрессивных расстройств на развитие и исход сердечно-сосудистых заболеваний. Терапевтический архив. 2006; 78(11): 87-92.

[3] Ханин Ю.Л. Краткое руководство к применению шкалы реактивной и личностной тревожности Ч.Д. Спилбергера. Л.: ЛНИИ ФК; 1976.

[4] Андрющенко А.В., Дробижев М.Ю., Добровольский А.В. Сравнительная оценка шкал CES-D, BDI и HADS(d) в диагностике депрессий в общемедицинской практике. Журнал неврологии и психиатрии. 2003; 5: 11-8.

[5] Рубинштейн С.Я. Экспериментальные методики патопсихологии и опыт применения их в клинике: Практическое руководство. СПб.; 1998.

[6] Вассерман Л.И., Иовлев Б.В., Беребин М.А. Методика для диагностики уровня социальной фрустрированности и ее практическое применение: методические рекомендации. СПб.; 2004.

[7] Holmes Т., Rahe R. The Social Readjustment Rating Scale. J. of Psychosomatic Research. 1967; 11: 213-8.

[8] Климов А.Н., Никульчева Н.Г. Обмен липидов и липопротеидов и его нарушения. СПб.: Питер ком; 1999. (Серия "Практическая медицина").

[9] Диагностика и коррекция нарушений липидного обмена с целью профилактики и лечения атеросклероза; Российские рекомендации V пересмотр. Москва; 2012.

[10] Bachen E.A., Muldoon M.F., Matthews K.A., Manuck S.B. Effects of hemoconcentration and sympathetic activation on serum lipid responses to brief mental stress. Psychosomatic Medicine. 2002; 64(4): 587-94.

[11] Панин Л.Е. Обмен липопротеинов и атеросклероз. Бюллетень СО РАМН. 2006; 120(2): 15-22.

[12] Гарганеева Н.П. Психосоциальный стресс и метаболизм липидов: концепция факторов риска и новый подход к профилактике сердечно-сосудистых заболеваний. Российский медицинский журнал. 2008; 12(6): 1712-9.

[13] Кемпинский А. Экзистенциональная психиатрия. М.: 2005.

RIGHTS & PERMISSIONS

Eco-Vector