THE APPLICATION OF 99mTc-LABELED ANTIBACTERIAL PREPARATIONS IN SCINTIGRAPHIC DIAGNOSTICS OF INFECTIVE INFLAMMATION
S. I Sazonova , N. V Varlamova , Yu. B Lishmanov
Russian Medicine ›› 2013, Vol. 19 ›› Issue (2) : 39 -42.
THE APPLICATION OF 99mTc-LABELED ANTIBACTERIAL PREPARATIONS IN SCINTIGRAPHIC DIAGNOSTICS OF INFECTIVE INFLAMMATION
The article considers the issues of radionuclide diagnostics of inflammatory processes using 99mTc-labeled antibacterial preparations. The modes of synthesis and perspectives of their implementation in nuclear medicine are discussed. The results of clinical studies of the mentioned group of radiology diagnostic remedies are contradictory though indicate at the possibility of using then to differentiate infective and aseptic inflammation. As compared to traditionally used in scintigraphic diagnostics the radiologic pharmacologic preparations on the basis of radionuclide-labeled autologic leucocytes (99mTc- and 111Inlabeled leucocytes) the antibiotics have a significant advantage related to making of radiologic pharmacologic preparations. Taking into account the character of physiologic allocation of indicators on the basis of antibacterial remedies, (the higher accumulation in abdominal organs) the mostly probable area of their application is the scintigraphic diagnostics of infective inflammatory diseases of bones and joints.
infective inflammatory diseases of bones and joints / radiologic pharmacologic preparations / diagnostics
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