THE DECREASE OF EMIGRATION OF T-LYMPHOCYTES FROM THYMUS UNDER THYMOMEGALIA IN CHILDREN OF EARLY AGE
P. D Vaganov , A. D Donetskova , N. F Nikonova , I. M Danko , A. A Yarylin
Russian Medicine ›› 2012, Vol. 18 ›› Issue (5) : 27 -29.
THE DECREASE OF EMIGRATION OF T-LYMPHOCYTES FROM THYMUS UNDER THYMOMEGALIA IN CHILDREN OF EARLY AGE
The article demonstrates that in children aged less than 5 years the content of so called T-receptor excisional rings in mononuclears of peripheral blood is significantly (more than six-fold times) decreased. The T-receptor excisional rings are formed in the process of changes of genes of T-cell receptor in thymocytes. In the peripheral part of immune system (blood included) T-receptor excisional rings are present only in T-cells, recently migrated from thymus. The content of T-receptor excisional rings in mononuclears reflects the intensity of T-lymphocytes maturation and their emigration from thymus. Therefore, the content of T-receptor excisional rings in mononuclears of blood can be considered as an indicator of thymus functional activity. With age, the content of T-receptor excisional rings in peripheral T-cells steadily decreases. The research data signify that in children aged less than 5 years with thymomegalia the thymus functional activity is decreased as compared with age norm.
children / thymomegalia / T-lymphocytes / thymus functional activity
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