THE PATHOGENIC MECHANISMS OF DERANGED FUNCTIONAL ACTIVITY OF CELL MEMBRANES IN PATIENTS WITH DIABETES MELLITUS TYPE I AND PRIMARILY DETECTED DIABETES MELLITUS TYPE II
N. P Mikayelyan , V. V Potiyemkin , A. A Terentyev , I. O Kulayeva , Ye. Yu Frantzeva
Russian Medicine ›› 2012, Vol. 18 ›› Issue (4) : 20 -22.
THE PATHOGENIC MECHANISMS OF DERANGED FUNCTIONAL ACTIVITY OF CELL MEMBRANES IN PATIENTS WITH DIABETES MELLITUS TYPE I AND PRIMARILY DETECTED DIABETES MELLITUS TYPE II
In patients with diabetes mellitus type I and primarily detected diabetes mellitus type II the metabolic deficiency inherently occurs of aerobic synthesis of ATP as a result of of glycolytic processes activation, lactate concentration increase and lipid peroxidation development. The misbalance in the lipid peroxidation-antioxidant defense system against the background of dyshyperlipemia and lactate concentration increase testifies the development of oxidative stress, especially marked under diabetes mellitus type II. The degree decrease of glucose utilization by erythrocytes and inhibition of activity of K+, Na +-ATPase indicate the desensitivity of cells to insulin. The alterations of under study indicators depend on diabetes type and duration of disease course. The findings reflect the manifestation of common adaptive mechanisms in disease development which promote the adaptation to the negative impact of active forms of oxygen.
insulin receptor / glucose utilization by cells / enzyme-antioxidant / glucose-insulin homeostasis / metabolic status
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