Impact of the severity of undifferentiated connective tissue dysplasia on the development of nephrosclerosis and the course of pyelonephritis in children with congenital urinary tract abnormalities

Aneta Mukhamedovna Mambetova; R A Zhetishev; N N Shabalova; A M Mambetova; R A Zhetishev; N N Shabalova

doi:10.17816/rmj37986

Russian Medicine ›› 2011, Vol. 17 ›› Issue (5) : 34 -39. DOI: 10.17816/rmj37986

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Impact of the severity of undifferentiated connective tissue dysplasia on the development of nephrosclerosis and the course of pyelonephritis in children with congenital urinary tract abnormalities

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Abstract

The impact of the severity of undifferentiated connective tissue dysplasia (UCTD) on the production of tumor necrosis factors-α and interleukin-1β was evaluated in different types of congenital urinary tract abnormalities. Moderate UCTD was ascertained to stimulate the production of the above cytokines and to favor the development and progression of secondary complications as pyelonephritis and nephrosclerosis in patients with secondary urinary tract abnormalities. Analysis of cytokine production over time suggests the retention of the factors that contribute to the progression of nephrosclerosis and recurrences of pyelonephritis.

Keywords

undifferentiated connective tissue dysplasia (UCTD) / degree of severity / tumor necrosis factor-α / interleukin-1β / pyelonephritis / nephrosclerosis

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Aneta Mukhamedovna Mambetova, R A Zhetishev, N N Shabalova, A M Mambetova, R A Zhetishev, N N Shabalova. Impact of the severity of undifferentiated connective tissue dysplasia on the development of nephrosclerosis and the course of pyelonephritis in children with congenital urinary tract abnormalities. Russian Medicine, 2011, 17(5): 34-39 DOI:10.17816/rmj37986

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