THE RESPIRATORY SYSTEM CONDITION UNDER OBESITY

Abstract

The article deals with the study of respiratory system condition in patients with obesity of different mass degree. In the main group the medium and average invert correlation was derived between body mass index, waistline, index of waist volume/hip volume and ventilation indicators. The lowest indicators were established in males with third degree obesity. In this group the VC, FVC, EV1 and PEF were reliably lower than in males of control group. The same group demonstrated a high correlation between waistline, index of waist volume/hip volume, FVC, MEF50, FEV1 and FEF 25-75. The microscopy revealed that in all cases the main pathologic alterations in muscle tissue manifested as separation of myofibrils and disappearance of transversal banding, thinning and destruction of separate fibers with replacement of tissue fragments with adipose cells. The conclusion is made that the intensity of dysfunction of pulmonary ventilation depends on the degree and type of obesity.

Keywords

obesity / diaphragm / function of external respiration

References

[1] Бессесен Д. Г., Кушнер Р. Избыточный вес и ожирение. Профилактика, диагностика и лечение: Пер. с англ.; Под ред. И. М. Балкарова. — М.: БИНОМ, 2004.

[2] Дедов И. И., Мельниченко Г. А., Романцова Т. Н. // Ожирение и метаболизм. — 2005. — Т. 12, № 3. — C. 9—14.

[3] Yamane T., Date T., Tokuda M. et al. // Am J. Respir. Crit. Care Med. — 2008. — Vol. 178, N 3. — P. 295—299.

[4] Borel J. C., Tamisier R., Gonzalez-Bermejo J. et al. // Chest. — 2012. — Vol. 141, N 3. — P. 692—702.

[5] Bua J., Prescott E., Schack-Nielsen L. // Int. J. obes. — 2005. — Vol. 29. — P. 1055—1062.

[6] De Lorenzo A., Maiolo C., Bruno E. et al. // Eur. Arch otorhinolaryngol. — 2009. — Vol. 266. — P. 1285—1290.

[7] Ferretti A., Giampiccolo P., Cavalli A. et al. // Chest. — 2001. — Vol. 119, N 5. — P. 1401—1408.

[8] Hancox R. J., Milne B. J., Taylor D. R. et al. // Thorax. — 2004. — Vol. 59. — P. 376—380.

[9] Jakes R. W., Day N. E., Patel B. et al. // Am. J. Epidemiol. — 2002. — Vol. 156. — P. 139—147.

[10] Jedrychowsky W., Tobiasz-Adamczyk, Flak E. et al. // Environ. Int. — 1990. — Vol. 16. — P. 57—60.

[11] Jensen D., Ofir D., O'Donnell D. E. // Respir. Physiol. Neurobiol. — 2009. — Vol. 167, N 1. — P. 87—100.

[12] Magnani K. L., Cataneo A. J. // Sao Paulo Med. J. — 2007. — Vol. 125, N 4. — P. 215—219.

[13] Mokhlesi B., Tulaimat A. // Chest. — 2007. — Vol. 132, N 4. — P. 1322—1336.

[14] Ochs-Balcom H. M., Grant J. B., Muti P. et al. // Am. J. Epidemiol. — 2005. — Vol. 162, N 12. — P. 1137—1145.

[15] Partinen M., Jamieson A., Guilleminault C. // Chest. — 1988. — Vol. 94. — P. 120—1204.

[16] Poulain Magali, Doucet Mariève, Major Geneviève C. et al. // Can. Med. Assoc. J. — 2006. — Vol. 174, N 9. — P. 1293—1299.

[17] Santana A. N., Souza R., Martins A. P. et al. // Respir. Med. — 2006. — Vol. 100, N 6. — P. 1100—1104.

[18] Schachter L. M., Salome C. M., Peat J. K. et al. // Thorax. — 2001. — Vol. 56. — P. 4—8.

[19] Schwartz A. R., Patil S. P., Laffan A. M. et al. // Proc. Am. Thorac. Soc. — 2008. — Vol. 5, N 2.

[20] Sood A. // Clin. Chest Med. — 2009. — Vol. 30, N 3. — P. 445—454.

[21] Stalnecker M. C., Suratt P. M., Chandler J. G. // Surgery. — 1980. — Vol. 87, N 6. — P. 645—651.

[22] Stelfox H. T., Ahmеd S. B., Ribeiro R. A. et al. // Crit. Care Med. — 2006. — Vol. 34, N 4. — P. 1243—1246.

[23] Taylor B. A., Brown C., Crocker D. et al. Body mass index as a predictor of asthma severity in adult asthmatics. Results from the 4-state national asthma survey. — Atlanta, 2007.

[24] Vakili B. A., Okin P. M., Devereux R. B. // Am. Heart J. — 2001. — Vol. 141. — P. 334—341.

[25] Wannamethee S. G., Shaper A. G., Lennon L., Whincup P. H. // Am. J. Clin. Nutr. — 2007. — Vol. 86, N 5. — P. 1339—1346.

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