Analysis of dynamic endothelial cell density loss after corneal endothelial transplantation
Oganes Georgievich Oganesyan , V V Neroev , R A Gundorova , M A Smetanina , D Yu Danilova , O G Oganesyan , V V Neroyev , R A Gundorova , M A Smetanina , D Yu Danilova
Russian Medicine ›› 2011, Vol. 17 ›› Issue (4) : 32 -36.
Analysis of dynamic endothelial cell density loss after corneal endothelial transplantation
Dynamic endothelial cell loss is an inevitable process that is inherent in the endothelium of the cornea, including transplanted one, and affects late graft survival. The aim of this communication is to analyze endothelial cell density (ECD) loss after endothelial transplantation by modified DSEK and DMEK techniques. The analysis is based on a follow-up of ECD in 163 patients undergoing endothelial keratoplasty by the modified DSEK and DMEK techniques. The follow-up lasted 10-55 months. Endothelial microscopy was performed using an endothelial contactless microscope 1, 3, 6, and 12 months postoperatively and then every year. Dynamic EDC loss was calculated using the preoperative donor ECD. The EDC losses were 20.8±12.9, 26.3±12, and 32.3±12.5% within the first 12, 24, and 36 months after DSEK, respectively. The EDC decreases were 8.4±14.8, 20.5±13.4, 25.1±15.3, and 33.2±15.4% within the first month, the first 6, 12, 24 months following DMEK, respectively. The EDC loss after endothelial keratoplasty (DSEK and DMEK) was less than that given in the literature, which is conjecturally associated with the native pattern of a graft. This communication is the first in the Russian literature on this topic.
DMEK / DSEK / DMEK / DSEK / microinvasive descemetoplasty / endothelial dystrophy / endothelial keratoplasty / endothelial cell density
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