PORAZhENIE SERDTsA U DETEY S OSTRYM TEChENIEM VNUTRIUTROBNOY TsITOMEGALOVIRUSNOY INFEKTsII

Abstract

Clinical, instrumental, and enzymological studies were carried out in 15 children with the acute course of intrauterine cytomegalovirus infection (CMVI) to estimate the extent and depth of cardiac disorders. A control group consisted of 15 noninfected children. The specific features of cardiac lesion and the level of cardiac enzymes were studied in children with CMVI. Irrespective of the severity of cardiac pathology, enzymemia was ascertained to reflect the depth of cardiomyocyte morphological changes. The remaining high levels of enzymes over time are indicative of the on-going cardiac morphological changes in the persistent course of the disease, which lead to the development of chronic cardiac diseases.

Keywords

intrauterine cytomegalovirus infection / cardiac markers / cardiomyocytes / enzymemia / cardiac disorder

References

[1] Березов Т. Т., Коровкин Б. Ф. Биологическая химия. 2-е изд. - М., 1990.

[2] Власов В. В. Введение в доказательную медицину. - М., 2001.

[3] Ермолаев М. В. Особенности углеводного обмена у детей: Учебно-метод. пособие. - М., 1990.

[4] Козлов А. В. // Лаб. диагн. - 2005. - № 2. - С. 3-8.

[5] Chiu A., Chan W., Cheng S. et al. // Quart. J. Med. - 1999. - Vol. 92, N 12. - P. 711-718.

[6] Reinhard Dettmeyer, Jan P. Sperhake, Jutta Müller, Burkhard Madea. Department of Forensic Medicine, University Medical Center Hamburg, Germany Received 4 April 2006; revised 6 March 2007; accepted 6 May 2007. Available online 13 June 2007.

[7] Wu A. H. B. Diagnostic enzymology and other biochemical markers of organ damage. - Ed. McClatchey. - 2-nd Ed. - Philadelphia, 2002. - P. 281-305.

RIGHTS & PERMISSIONS

Eco-Vector