Markers of tumor cell proliferation in cancerous tumors of the larynx
S. V. Petrov , R. N. Kulagin , D. E. Tsyplakov , O. V. Nefedov , V. V. Saveliev , A. R. Utkuzov , N. T. Raikhlin
Kazan medical journal ›› 2000, Vol. 81 ›› Issue (4) : 265 -268.
Markers of tumor cell proliferation in cancerous tumors of the larynx
The cell proliferative process in the larynx cancer is studied. Contrary to the classical mitotic index the Ki-67 and PCNA indices are reliable and reproducible on the clinical material by the proliferative cell activity indices of the larynx tumors. There is a reverse connection between the proliferation index in cells of the squamous larynx cancer and the tumor differentiation. The direct correlation of the cell proliferation index of the squamous laxynx cancer with the disease stage is revealed. The preoperative radiation therapy significantly decreases the cell proliferation rates of the squamous larynx cancer.
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