Activation of factor XII clotting
I. M. Baishev
Kazan medical journal ›› 1988, Vol. 69 ›› Issue (5) : 371 -375.
Activation of factor XII clotting
The origins of modern concepts of contact activation of blood clotting go back to the middle of the last century. In 1862, Lister drew attention to the fact that sheep's blood collected in a rubber test tube remained flowing significantly longer than that placed in a glass or ceramic cup. It was also observed that blood clotting was slower in tubes coated inside with oil or Vaseline. As a result, it was believed that blood-wetted contact surfaces (glass, etc.) promote rapid coagulation of liquid blood or plasma, while non-wetted (like paraffin), on the contrary, slow the clotting process.
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