Effects of Heparin and Piyavit on blood rheological properties and platelet aggregation
M. V. Kameneva , A. S. Parfenov , E. L. Klimanova , S. Khalil , G. I. Nikonov , I. P. Baskova
Kazan medical journal ›› 1988, Vol. 69 ›› Issue (5) : 331 -334.
Effects of Heparin and Piyavit on blood rheological properties and platelet aggregation
Heparin in clinical practice is used either to prevent thrombosis or during extracorporeal hemoperfusion (hemo- and plasmabsorption, operation of artificial circulation devices and blood fractionators). Currently, indications for administration of heparin for therapeutic purposes tend to be limited. This is due to the fact that the vast experience of heparin therapy has revealed not only the favorable effects of heparin, consisting in its hypocoagulation action, but also the possibility of the development of various complications of its use. These adverse effects of heparin include primarily thrombocytopenia associated with intravascular platelet aggregation. In addition, in certain situations, heparin is able to block the action of antithrombin III in case of severe thrombinemia and antithrombin deficiency. Recently, data have appeared about the increase of platelet factor 4 concentration in plasma of patients with peripheral atherosclerosis during intravenous injection of heparin. Consequently, the search for compounds capable of replacing heparin is highly relevant.
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