Detection of hemocoagulative activity of leukemia cells in acute myeloid leukemia and chronic myeloid leukemia

Abstract

Peripheral blood and punctates taken in 13 primary patients, 6 of which had acute myeloblastic leukemia and 7 — chronic myeloleukemia are studied. The peripheric blood in 3 healthy volunteers is studied for control. The method of revealing the tissue factor activity in blood cells of patients with leukemia is suggested. Previously described expression of the tissue factor by myeloblasts of patients with acute myeloblastic leukemia in peripheral blood as well as in bone marrow punctates is confirmed. It is shown that in patients with chronic myeloleukemia expression of the tissue factor activity is carried out by myeloblasts in peripheral blood as well as in bone marrow punctates. The results contradict the conception maintaining the principal impossibility of forming principal the tissue factor by blood cells. The development of disseminated intravascular blood coagulation syndrome and hemophilia under the influence of the tissue factor in leukocytes is possible not only in acute myeloblastic leukemia but in chronic myeloleukemia.

Keywords

Kazan Medical archive

References

[1] Абдулкадыров К.М., Бессмелъцев С. С., Рука- вицин О.А. Хронический миелолейкоз,—СПб, 1998.

[2] Зубаиров Д.А/.//Казанский мед. ж.— 1988.— №5.-С. 321-329.

[3] Зубаиров Д.М., Байкеев Р.Ф.//Лабор. дело.— 1991.—№12.—С.25—28.

[4] Литвинов А//.//Казанский мед. ж.—2000.— № 1.-С. 48-52.

[5] Bauer К.А., Conway Е.М., Bach R. et al.//Thromb. Res.-1989.-Vol. 56.-P. 425-430.

[6] Friesen C., Fulda S., Debatin A.A/.//Leukemia — 1997,—Vol. 1 l.—P.1833—1841.

[7] Iijima N., Miyamura K., Itou T, Tanimoto M., Sobue R., Saito //.//Blood.—1997.—Vol. 90.— P.4901 — 4909.

RIGHTS & PERMISSIONS

Eco-Vector