Study of the local irritating effect of suppositories with gabutamine
S. A. Sidullina , P. P. Dementieva
Kazan medical journal ›› 2000, Vol. 81 ›› Issue (2) : 149 -150.
Study of the local irritating effect of suppositories with gabutamine
In the practice of anticonvulsant therapy, a significant arsenal of drugs is used. In recent years, it has been established that nitrogen-containing derivatives of trichloromethylpropanoic acid are mainly low-toxic compounds with pronounced anticonvulsant and anti-tremor effects. Among them, one can distinguish a new original biologically active substance habutamine - 1,3dichloro-2-chloromethylaminopropane hydrochloride, obtained at the Kazan Research Institute of Chemical Products. Based on the pharmacological effect of gabutamine, studied at the Department of Pharmacology of the KSMU, and the possibility of its use in all age groups, a rational dosage form was proposed - rectal suppositories.
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