Retinoic acid preparations in the complex treatment of acute promyelocytic leukemia

V. V. Cherepanova , N. A. Medvedeva , L. N. Tarasova , E. P. Svedentsov , A. V. Kudryavtseva , V. A. Hovsepyan , G. K. Platonov , V. N. Minakov , A. I. Kostin

Kazan medical journal ›› 2000, Vol. 81 ›› Issue (1) : 18 -26.

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Kazan medical journal ›› 2000, Vol. 81 ›› Issue (1) : 18 -26. DOI: 10.17816/kazmj96225
Theoretical and clinical medicine
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Retinoic acid preparations in the complex treatment of acute promyelocytic leukemia

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Abstract

The results of the treatment of 11 patients with acute promyelocyte leukosis using the retinoic acid drugs (ATRA, 13-cis-retinoic acid) are presented. Total remission was achieved in 6 out of 9 patients within 22—39 days of treatment: in 2 patients — on ATRA monotherapy and in 4 patients — in combination with polychemotherapy. Normalization of hemostasis indices with tendency to hypercoagulation is noted during the first week. Cupping of hemorrhages took place within 14—30 days of treatment. High incidence (67%) of the retinoic acid syndrome is noted. It is connected with the initial hyperleukocytosis and not always timely prescription of polychemotherapy. Less dramatic nature of the disease course, fast cupping of hemorrhages, absence of the bone marrow aplasia phase, decrease of demand in transfusional provision were observed in using ATRA.

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V. V. Cherepanova, N. A. Medvedeva, L. N. Tarasova, E. P. Svedentsov, A. V. Kudryavtseva, V. A. Hovsepyan, G. K. Platonov, V. N. Minakov, A. I. Kostin. Retinoic acid preparations in the complex treatment of acute promyelocytic leukemia. Kazan medical journal, 2000, 81(1): 18-26 DOI:10.17816/kazmj96225

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