The effect of antireticular cytotoxic serum on the aorta elasticity in sclerous systolic hypertension

Abstract

It is known that pathogenesis of stable isolated sclerotic hypertension in elderly and senile patients is mainly caused by decreased elastic properties of aorta and large arteries due to age-related and, to a lesser extent, atherosclerotic changes. Loss of elasticity impairs the adaptive capacity of the circulatory system, leads to increased energy expenditure per unit minute volume, and left ventricular myocardial hypertrophy. Sclerotic systolic hypertension is a risk factor for, firstly, cerebral strokes, increasing their frequency from 2 to 4 times, and secondly, myocardial infarctions, worsening their prognosis. Therefore, at the present time it is reasonable to strive for BP normalization in sclerotic systolic hypertension in old age and old age. Meanwhile, hypotensive drug therapy of systolic hypertension is ineffective, because it is aimed not on the primary, but on the secondary links of blood pressure regulation. Thus, vasodilators, which reduce peripheral resistance, saluretics, which reduce circulating fluid volume, beta-adrenoblockers, which reduce cardiac output, only temporarily reduce systolic pressure. Vigorous and persistent therapy with these medications can lead to a significant reduction in blood flow to the brain and other regions.

Keywords

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