Imbalance in the nicotinamide coenzyme system in myocardial infarction

Abstract

The study of cardiac muscle metabolism is of significant interest due to the specificity of metabolism and function, the frequency of cardiac lesions, observed in most cases against the background of atherosclerotic process, polymorphism and severity of myocardial infarction course. It is known that in the heart muscle, depending on the conditions, mainly glucose, fatty acids, ketone bodies, lactate, amino acids are utilized as energy substrates. The possibility of autonomous synthesis of NAD-coenzymes apparently contributes to the provision of multidisciplinary enzymatic processes for catabolism, energy supply, and anabolic transformations. There are reports in the literature about disruption of NAD+/NADH + H+ ratio in experimental myocardial infarction and in patients in the acute phase of the process.

Keywords

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References

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