Comparative study of paracoagulation tests in acute myocardial infarction

Abstract

Ethanol, ß-naphthol (test for "fibrinogen B") and protamine sulfate tests, performed simultaneously in the blood plasma of patients with acute myocardial infarction, showed a high degree of correlation with each other, but they differed in sensitivity: ethanol> ß-naphthol> protamine sulfate. Heparin did not distort the results of the ethanol and β-naphthol tests, while the protamine sulfate test results strongly depended on the presence of heparin. The formation of a granular precipitate is not a positive protamine sulfate test and indicates hyperheparinemia. The ethanol test on the basis of data can be recommended to monitor the state of the hemocoagulation system in acute myocardial infarction, including the period of heparin therapy.

Keywords

myocardial infarction / paracoagulation tests / heparin

References

[1] Грицюк А. И., Щигельский В. И. Тер. арх., 1979, 1

[2] 3убаиров Д. М., Щербатенко-Лушникова Л. А., Андрушко И. А. и др. В кн.: Материалы международной конф. «Противотромботическая терапия в клинической практике». Тез. докл., М., 1979

[3] Зубаиров Д. М., Литвинов Р. И. Биохимия, 1980, 6

[4] Люсов В. А., Белоусов Ю. Б., Бокарев И. Н. Лечение тромбозов и геморрагий в клинике внутренних болезней. М., Медицина, 1976

[5] Рутберг Р. А. Лаб. дело, 1961, 5

[6] Аnауа-Са1іndо R., Shattil S. J., Shelburne J. С., Coloman R. W. Thrombos. Res., 1976, 9, 2

[7] Breen F. A., Jr., Tullis J. L. Ann. Intern. Med., 1968, 69, 6

[8] Conard J., Bogaty-Yver J., Samama M. Nouv. Presse med., 1974, 3, 44

[9] Cummine H., Lyons R. N. Brit. J. Surg., 1948, 35, 140

[10] Fung C.H. K, Woodson B. Amer. J. Clin. Pathol., 1976, 65, 5

[11] Godal H. C., Brosstad F., Kierulf P. Bibl. haematol., 1978, 44

[12] Gurewich V. Thrombos. Diathes. haemorrh., 1973, 29, 733

[13] Gurewich V., Lipinski B. Am. J. Clin. Pathol., 1976, 65, 3

[14] Gurewich V., Lipinski B., Lipinska I. Thrombos. Res., 1973, 2, 539

[15] Konttinen Y. Р. Kemppainen L., Turunen O. Thrombos. Diathes. haemorrh., 1972, 28, 3

[16] Latallo Z. S. Ibid., 1975, 34, 3

[17] Nowak A., Lipinski B., Drzewiecki J. Brit. Heart. J., 1972, 34, 593

[18] Pieptea R. M. Sang, 1957, 28, 91

[19] Sas G., Blasko G., Jако J., Banhegyi D. Haematologia, 1973, 7, 3—4

[20] Slaastad R. A., Godal H. C„ Kierulf P. Scand J. Haematol., 1975, 15, 2

[21] Vorlova Z., Pribylova J. Vnitrnilék., 1976, 22, 10

RIGHTS & PERMISSIONS

Eco-Vector