Clinical significance of the study of the platelet link of hemostasis in viral hepatitis

S. N. Sorinson; V. E. Kozulin

doi:10.17816/kazmj88002

Kazan medical journal ›› 1983, Vol. 64 ›› Issue (4) : 251 -254. DOI: 10.17816/kazmj88002

Clinical medicine

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Clinical significance of the study of the platelet link of hemostasis in viral hepatitis

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Abstract

The decisive importance in the pathogenesis of hemostasis disorders in viral hepatitis is mainly attributed to a decrease in the content of plasma coagulation factors. The development of an extensive cytolytic process in the liver explains the violation of the synthesis of prothrombin, proaccelerin, proconvertin, partially fibrinogen, a disorder of the regulation of fibrinolysis [1, 4]. Changes in the platelet link of hemostasis in viral hepatitis are completely insufficiently covered in the literature [5, 10]. At the same time, it is known that at the initial stages of hemostasis disorders, it is the platelet link that plays the leading role. This is due to angiotrophic (maintaining the normal state of microvascular walls), adhesive-aggregation (the property of forming a primary platelet plug), concentration-transport (adsorption of many coagulation factors) functions, the ability to maintain microvascular spasm and inhibitory effect on fibrinolysis [2].

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S. N. Sorinson, V. E. Kozulin. Clinical significance of the study of the platelet link of hemostasis in viral hepatitis. Kazan medical journal, 1983, 64(4): 251-254 DOI:10.17816/kazmj88002

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