Effect of dimephosphone on the dynamics of intracellular calcium
R. A. Giniatullin , R. R. Giniatullina , E. M. Sokolova , R. S. Garaev , A. O. Vizel
Kazan medical journal ›› 2001, Vol. 82 ›› Issue (2) : 132 -133.
Effect of dimephosphone on the dynamics of intracellular calcium
Intracellular ionized calcium ([Ca2 +] i) - ICIC - is a universal secondary messenger. The physiological signal leading to an increase in its level may be the action of hormones, mediators, trophic agents and other factors. A change in its level may underlie the mechanism of action of a number of drugs. However, until now, only calcium antagonists have become known, which inhibit the entry into the cell of extracellular FCCI. At the end of the 80s, modern methods for registering VKIK were proposed using highly sensitive non-toxic intracellular dyes that change the fluorescent signal with an increase in the concentration of ionized calcium in the cell. This opened up new opportunities for in-depth study of the mechanism of the effect of drugs on the dynamics of intracellular calcium.
Giniatullin R.A., Giniatullina R.R., Sokolova E.M., Garaev R.S., Vizel A.O.
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