Clinical tolerance of single doses of ethionamide in patients with pulmonary tuberculosis

Abstract

The tolerance of ethionamide was studied in 851 patients with pulmonary tuberculosis. The drug was administered at 0.75 g at a time. Side effects were noted in 31% of individuals, and complete intolerance - in 6.6%. For the rest, adverse reactions disappeared after a short break in taking the drug or when it was administered at night. In a number of patients, to remove side effects, it was necessary to reduce a single dose of ethionamide to 0.5 g or give it 0.25 g three times. More often, side complications occurred in persons with chronic diseases of the gastrointestinal tract, as well as in elderly and senile patients.

Keywords

pulmonary tuberculosis / ethionamide / Kazan Medical archiv

References

[1] Герасимов А. И., Ганущак М. М. и др Проблю туб. 1973

[2] Уткинкин В В. Там же 1973, 9.

[3] Хоменко А. Г., Шмелев Н. А., Каминская А. А. и др Там же, 1976,3.

[4] Шмелев Н. А., Каминская А. А. и др Там же, 1973, 9.

[5] Bhatia J. G., Gal H. Ind. J. Tuberc., 1966, 13, 2.

[6] Enle H. Z. Tuberk., 1965, 123, 4/6.

[7] Enle H. Werner E. Tuberk — Arzt., 1961, 12, 806,

[8] Moisesku R. У Ftiziologia, 1973, 22, 3,

[9] Schwartz W. S. Am. Rev. resp. Dis., 1966, 93r 5,

[10] Seidel H. Therapiewoche, 1970, 20, 8.

[11] Sighart H. Pneumonologie, 1971, 145, 348.

[12] Simane Z., Кraus P. Rozhl. Tuberk., 1962, 4, 289.

RIGHTS & PERMISSIONS

Smirnov G.A., Zamaletdinova L.T., Mikhailovskaya V.A., Latypova S.I.