Histamine therapy of gastric ulcer and duodenal ulcer

Abstract

The treatment of painful crises in peptic ulcer disease with low doses of histamine was proposed by Jacob and Israel. By using histidine in the treatment of ulcer patients, they obtained an excellent therapeutic effect. But they noticed that in some patients histidine injection produced symptoms of shock, transient leukopenia and lowering of arterial blood pressure. This led the authors to speculate that the histidine solution also contained histamine, which is derived from histidine by cleavage of the carboxylic group.

Keywords

Kazan Medical archive

References

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[6] Lambling, Soc. de gastro-enterologie de Paris. 10 Janvier 1938.

[7] Lambling, La presse medicale. 1938. № 26.-8. Zondek, Klin. Woch. № 3, 1923.

[8] V. Bergmann, Berl. kl. Woch. 1913. Best and Mc. Henry J. Physiol., vol. 70, 1930.

RIGHTS & PERMISSIONS

Kobyzev A.S., Kogan L.S.