The effect of vitamin B15 (pangamic acid) on clinical symptoms and humoral disorders in coronary atherosclerosis

Abstract

Vitamin B15 (pangamic acid) by chemical structure is an ester compound of gluconic acid with methylated glucin - dimethylglucin. Pangamic acid contains several methyl groups that are labile. According to Tsamp (1958), it is mainly methyl groups that determine the biological activity of vitamin Bis. He believes that the more methyl groups it contains, the higher the activity of the drug. Pangamic acid, due to the lability of its methyl groups, is a good donor of these groups (Beard and Wofford, 1956, Maniantini, 1959) Labile methyl groups are easily precipitated, and remethylation serves to activate oxidative processes and cellular respiration.

Keywords

Kazan Medical archive

References

[1] Анисимов В. Е. Казанский мед. ж. 1963, 5; Материалы конференции по атеросклерозу, Казань, мединститут, 1963; Лаб. дело, 1963, 11

[2] Гаркина И. п. Вопросы мед. химии, 1962, вып. 3

[3] Докукин А. В., Чечулин Ю. С., Константинова 3. С., Букин Ю. В. Доклады Академии наук СССР, 1962, т. 144, 3,

[4] Окунев Н. В. и Благоразумова М. А. Биохимия, 1949, 4.

[5] Удалов Ю. Ф. ДАН СССР, т. 143, 3.

[6] Beard H. U., Wofford и. Exper. Med. Surg., 1956, v. 14; Minerva med., 1957, v. 48.

[7] Bertelli A., Соsentini S. Boll. Soc. ital. Biol sper., 1957, v. 37.

[8] Cugudda E., Dispensa E. Minerva med., 1957, v. 48

[9] Dalmo Ciria M. Med. clin- 1958, 5

[10] Idzumia. Vitamin., 1959, 4.

[11] Krebs E. T. et al. Inter. Record. Med., 1951 164, 18

[12] Leone A., Longaretti P., Lucehelii. Minerva med., 190A v. 48

[13] Maniantini M. T. Ricercascient., 1959, 10

[14] Pestel M. Presse med 1958, 19

[15] Vailati G., Invernizzi G. Minerva med., 1957, 48.- Ю- Zampa G. A. J. clin, med., 1958, v. 39.

RIGHTS & PERMISSIONS

Anisimov V.E., Salikhov I.G., Anisimova I.A.