On the specificity of the tuberculin reaction
V. M. Aristovsky
Kazan medical journal ›› 1926, Vol. 22 ›› Issue (2) : 228 -234.
On the specificity of the tuberculin reaction
The classic studies of R. Koch'a showed for the first time that an organism infected with tbc reacts in a completely different way to the introduction of tbc cultures and various cultures derived from them. drugs than a normal animal that has not yet had a chance to get acquainted with the tbc antigen. Koch's main experiments boil down to the following: if you inject a healthy guinea pig with a pure culture of tbc rods, then, as a rule, the wound at the site of the injection heals up and seems to heal in the first days: however, then, within 10-14 days, a solid a nodule that soon opens and forms a place ulcerating until the death of the animal; at the same time, swelling of the nearest lymph glands develops, and later the generalization of the process occurs.
Aristovsky V.M.
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