Influence of dimephosphone on myelotoxic side effect of cytostatic therapy of malignant neoplasms
I. S. Mokrinskaya , I. A. Studentsova , R. H. Khafizyanova , N. N. Novozhilova , L. N. Zalyalyutdinova , S. Z. Сафина , F. Sh. Akhmetzyanov
Kazan medical journal ›› 1995, Vol. 76 ›› Issue (3) : 218 -219.
Influence of dimephosphone on myelotoxic side effect of cytostatic therapy of malignant neoplasms
This paper presents the results of studying the effect of dimephosphone in combination with cyclophosphamide on the hematological parameters of tumor-carrying animals, as well as in combination with polychemotherapy in patients with malignant neoplasms. The experimental part of the work was carried out on 50 rats with transplanted ascitic ovarian tumor. One day after the transplantation of the tumor, the animals were divided into groups of 10 animals each. The rats of the control group were injected intraperitoneally with distilled water, the 1st experimental group received dimephosphone in the stomach at a dose of 200 mg/kg, the 2nd group received intraperitoneal cyclophosphamide at a dose of 10 mg/kg, the 3rd group received cyclophosphamide and dimephosphone at the same doses. The drugs were administered daily for 9 days. Intact animals were taken for comparison of indicators.
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