Synthesis, properties and biological activity of bis(diphenylphosphinylacetyl)hydrazine and its complex with iron (III)
R. I. Tavasova , V. V. Moskva , O. V. Voskresenskaya , A. V. Litvinenko , I. I. Semina , A. Z. Baichurina , G. F. Rzhevskaya
Kazan medical journal ›› 1995, Vol. 76 ›› Issue (3) : 193 -196.
Synthesis, properties and biological activity of bis(diphenylphosphinylacetyl)hydrazine and its complex with iron (III)
The synthesis of bis (diphcnulphosphinylacetyl)hydrazine and its complex with iron (III) chloride is performed, their ultraviolet and infrared spectrums are investigated, the method of titrimetric determination of iron in the complex is developed. The initial ligand offers tranquilizing, antidepressive activity and does not affect the lenth of ethanol anesthesia of rats, and its complex with iron (III) chloride potentiates the lenth of ethanol anesthesia more than 3 times, however, does not manifest tranquilizing and antidepressive activity. Both of the products are low toxic compounds.
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