Impaired platelet haemostasis in patients with myelodysplastic syndrome
A. S. Shitikova , O. E. Belyazo , E. A. Ushakova , V. V. Kuraleva
Kazan medical journal ›› 1989, Vol. 70 ›› Issue (4) : 261 -265.
Impaired platelet haemostasis in patients with myelodysplastic syndrome
One third of patients with myelodysplastic syndrome die before the development of leukemia from infectious and hemorrhagic complications; after the onset of acute myeloleukemia this figure reaches 59%. Therefore, the relevance of studying hemostatic disorders in preleukemic conditions is dictated primarily by the need to preserve the lives of patients. Literature data indicate the absence of significant changes in the plasma-coagulation component of hemostasis and fibrinolytic processes. At the same time, hematopoietic dysfunction in myelodysplastic syndrome necessarily includes megakaryocytic bone marrow, which cannot but affect the functional state of the platelet apparatus, the assessment of which was the main task of this work.
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