On the problem of improving methods for recruiting potential bone marrow donors in the Russian population

Abstract

BACKGROUND: To achieve the number of potential bone marrow donors in Russian registries to a level sufficient for effective selection of recipients in need of transplantation, it is important to find the most effective ways to recruit Russians as potential bone marrow donors.

AIM: To identify areas for improving methods of recruiting potential bone marrow donors in the Russian population.

MATERIAL AND METHODS: An electronic survey was conducted: the questionnaire included 27 questions, the respondents were participants in the register of potential bone marrow donors of the Vasya Perevoshchikov National Register of Bone Marrow Donors Charitable Foundation, expert validation and a preliminary pilot survey were used. The focus was on factors that determine the population’s readiness to donate, preferred methods of donating biomaterial and territorial accessibility of recruitment centers, opportunities and obstacles to recruiting bone marrow donors. 6,314 people took part in the survey. The work used frequency analysis methods and the Pearson χ² statistical criterion; the data was processed in the SPSS Statistics program.

RESULTS: The most common channels of information about bone marrow donation in the process of involving potential registry participants were mass media (33.6%), social media (18.9%) and the social environment (18.4%). Among the respondents, 30% had experience in human blood donation. The social environment of donors included people who had experience in donating blood: among those surveyed, 48.5% indicated that their relatives served as blood donors; 67.7% noted that their friends were blood donors. For 40% of the registry participants, the method of submitting biospecimens was important. The majority (87%) of respondents indicated that submitting biospecimens at medical centers was the most convenient mechanism for joining the registry.

CONCLUSION: The media serve as an effective channel for informing the population; the role of new social media (Internet resources, social networks) is increasing. A significant factor in involvement in the register is the social environment, including people who have experience in donating blood.

Keywords

bone marrow donation / donation information / donor register / recruitment of donors / method of donating biomaterial / availability of biospecimen donation centers

References

[1] National Bone Marrow Donors Registry named after Vasya Perevoshchikov. Available from: https://rdkm.rusfond.ru/registr_stat Accessed: Jan 28, 2024.

[2] Национальный регистр доноров костного мозга имени Васи Перевощикова. Режим доступа: https://rdkm.rusfond.ru/registr_stat Дата обращения: 28.01.2024.

[3] Total Number of Donors and Cord blood units. Available from: https://statistics.wmda.info/ Accessed: Oct 6, 2023.

[4] Total Number of Donors and Cord blood units. Available from: https://statistics.wmda.info/ Accessed: Oct 06, 2023.

[5] Gosuslugi. Available from: https://www.gosuslugi.ru/donation Accessed: Jan 28, 2024.

[6] Госуслуги. Режим доступа: https://www.gosuslugi.ru/donation Дата обращения: 28.01.2024.

[7] Federal Register of Bone Marrow Donors.. Available from: https://kmdonor.ru/ Accessed: Oct 11, 2023.

[8] Федеральный регистр доноров костного мозга. Режим доступа: https://kmdonor.ru/ Дата обращения: 11.10.2023.

[9] Bubnova LN, Pavlova IE, Kuzmich EV, Terentyeva MA, Belyaeva EV, Glazanova TV, Sidorkevich SV. Development of the bone marrow donor registry of the Russian research institute of hematology and transfusiology of the FMBA of Russia. Transfuziologiya. 2022;23(2):171–183. (In Russ.) EDN: QVLPBI

[10] Бубнова Л.Н., Павлова И.Е., Кузьмич Е.В., и др. Развитие регистра доноров костного мозга Российского НИИ гематологии и трансфузиологии ФМБА России // Трансфузиология. 2022. Т. 23, № 2. С. 171–183. EDN: QVLPBI

[11] Khamaganova EG, Khizhinskiy SP, Abdrakhimova AR, Kuzminova EP, Leonov EA, Pokrovskaya OS, Kuzmina LA, Parovichnikova EN. Multilocus HLA haplotypes (A-B-C-DRB1-DRB3/DRB4/DRB5-DQA1-DQB1-DPA1-DPB1) in families of patients scheduled for allogeneic hematopoietic stem cell transplantation. Medical Immunology (Russia). 2024;26(2):291–302. (In Russ.) doi: 10.15789/1563-0625-MHH-2651

[12] Хамаганова Е.Г., Хижинский С.П., Абдрахимова А.Р., и др. Мультилокусные HLA-гаплотипы (A-B-C-DRB1-DRB3/DRB4/DRB5-DQA1-DQB1-DPA1-DPB1) в семьях больных с назначением к трансплантации аллогенных гемопоэтических стволовых клеток // Медицинская иммунология. 2024. Т. 26, № 2. С. 291–302. doi: 10.15789/1563-0625-MHH-2651

[13] Gerova O, Shikina I. Accessibility to join bone marrow donor registry for volunteers. Journal of Digital Art & Humanities. 2023;4(1):37–42. doi: 10.33847/2712-8148.4.1_5

[14] Gerova O., Shikina I. Accessibility to join bone marrow donor registry for volunteers // Journal of Digital Art & Humanities. 2023. Vol. 4, N. 1. P. 37–42. doi: 10.33847/2712-8148.4.1_5

[15] Makarenko OA, Kuzmich EV. Potential bone marrow donor: definition, criteria for the inclusion in the unrelated bone marrow donor register. Zdravookhranenie Rossiiskoi Federatsii. 2019;63(4):221–224. (In Russ.). doi: 10.18821/0044-197X-2019-63-4-221-224

[16] Макаренко О.А., Кузьмич Е.В. Потенциальный донор костного мозга: определение, критерии включения в регистр неродственных доноров костного мозга // Здравоохранение Российской Федерации. 2019. Т. 63, № 4. С. 221–224. doi: 10.18821/0044-197X-2019-63-4-221-224

[17] Makarenko OA, Kuzmich EV, Davydov SV, Zasukhina TN. Using the blood donors’ potential in the process of potential bone marrow donors registry creating. Transfuziologiya. 2019;20(4):323–335. (In Russ.) EDN: XJANKE

[18] Макаренко О.А., Кузьмич Е.В., Давыдов С.В., Засухина Т.Н. Использование потенциала доноров крови в процессе формирования регистра доноров костного мозга // Трансфузиология. 2019. Т. 20, № 4. С. 323–335. EDN: XJANKE

[19] Hyde MK, Masser BM, Coundouris SP. A review of whole-blood donors' willingness, motives, barriers and interventions related to donating another substance of human origin. Transfus Med. 2022;32(2):95–114. doi: 10.1111/tme.12849

[20] Hyde M.K., Masser B.M., Coundouris S.P. A review of whole-blood donors' willingness, motives, barriers and interventions related to donating another substance of human origin // Transfus Med. 2022. Vol. 32, N. 2. P. 95–114. doi: 10.1111/tme.12849

[21] La Casta AH., Shaw BE., Anthias C, Bruce JG., Pastorek G, Billen A, O'Leary A, Switzer GE. Motives for joining an unrelated HSC donor registry: Description, categorization, and association with donor availability. Bone Marrow Transplant. 2019;54(3):425–431. doi: 10.1038/s41409-018-0278-2

[22] La Casta A.H., Shaw B.E., Anthias C., et al. Motives for joining an unrelated HSC donor registry: Description, categorization, and association with donor availability // Bone Marrow Transplant. 2019. Vol. 54, N. 3. P. 425–431. doi: 10.1038/s41409-018-0278-2

[23] Garcia MC, Chapman JR, Shaw PJ, Gottlieb DJ, Ralph A, Craig JC, Tong A. Motivations, experiences, and perspectives of bone marrow and peripheral blood stem cell donors: Thematic synthesis of qualitative studies. Biol Blood Marrow Transplant. 2013;19(7):1046–1058. doi: 10.1016/j.bbmt.2013.04.012

[24] Garcia M.C., Chapman J.R., Shaw P.J., et al. Motivations, experiences, and perspectives of bone marrow and peripheral blood stem cell donors: Thematic synthesis of qualitative studies // Biol Blood Marrow Transplant. 2013. Vol. 19, No. 7. P. 1046–1058. doi: 10.1016/j.bbmt.2013.04.012

[25] Aurelio MT, Aniasi A, Haworth SE, Colombo MB, Dimonopoli T, Mocellin MC, Poli F, Torelli R, Crespiatico L, Serafini M, Scalamogna M. Analysis of the motivation for hematopoietic stem cell donation. Transplant Proc. 2011;43(4):981–984. doi: 10.1016/j.transproceed.2011.01.128

[26] Aurelio M.T., Aniasi A., Haworth S.E., et al. Analysis of the motivation for hematopoietic stem cell donation // Transplant Proc. 2011. Vol. 43, N. 4. P. 981–984. doi: 10.1016/j.transproceed.2011.01.128

[27] Bart T, Volken T, Fischer Y, Taleghani BM. Giving blood and enrolling on the stem cell donor registry: Ranking of obstacles and motives in Switzerland. Transfus Med Hemother. 2014;41(4):264–272. doi: 10.1159/000365457

[28] Bart T., Volken T., Fischer Y., Taleghani B.M. Giving blood and enrolling on the stem cell donor registry: Ranking of obstacles and motives in Switzerland // Transfus Med Hemother. 2014. Vol. 41, N. 4. P. 264–72. doi: 10.1159/000365457

[29] More than 43,000 people have joined the bone marrow donor registry at INVITRO medical offices. Available from: https://www.invitro.ru/moscow/about/press_relizes/bolee-43-000-chelovek-vstupili-v-registr-donorov-kostnogo-mozga-v-meditsinskikh-ofisakh-invitro Accessed: Oct 6, 2023.

[30] Более 43 000 человек вступили в регистр доноров костного мозга в медицинских офисах ИНВИТРО. Режим доступа: https://www.invitro.ru/moscow/about/press_relizes/bolee-43-000-chelovek-vstupili-v-registr-donorov-kostnogo-mozga-v-meditsinskikh-ofisakh-invitro Дата обращения: 06.10.2023.

[31] Bone marrow donation: a joint project of the Russian National Research Medical University named after N.I. Pirogov and CITILAB. Available from: https://citilab.ru/news/donorstvo_kostnogo_mozga_sovmestnyy_proekt_rnimu_im_n_i_pirogova_i_sitilab_/ Accessed: Oct 6, 2023.

[32] Донорство костного мозга: совместный проект РНИМУ им. Н.И. Пирогова и СИТИЛАБ. Режим доступа: https://citilab.ru/news/donorstvo_kostnogo_mozga_sovmestnyy_proekt_rnimu_im_n_i_pirogova_i_sitilab_/ Дата обращения: 06.10.2023.

[33] HLA typing for the bone marrow donor registry. Available from: https://kdl.ru/analizy-i-tseny/hla-tipirovanie-dlya-registra-donorov-kostnogo-mozga Accessed: Oct 6, 2023.

[34] HLA-типирование для регистра доноров костного мозга. Режим доступа: https://kdl.ru/analizy-i-tseny/hla-tipirovanie-dlya-registra-donorov-kostnogo-mozga Дата обращения: 06.10.2023.

[35] Almost 17,000 people applied to join the bone marrow donor register with the help of Russian Post. Available from: https://www.pochta.ru/news/item/post-389 Accessed: Oct 6, 2023.

[36] Почти 17 000 человек подали заявки на вступление в регистр доноров костного мозга с помощью Почты России. Режим доступа: https://www.pochta.ru/news/item/post-389 Дата обращения: 06.10.2023.

Funding

Работа выполнена за счёт средств Программы стратегического академического лидерства Казанского (Приволжского) федерального университета (ПРИОРИТЕТ 2030).The work was carried out with funds from the Strategic Academic Leadership Program of the Kazan (Volga Region) Federal University (PRIORITY 2030).

RIGHTS & PERMISSIONS

Eco-Vector