Jungeblut, C. W. Inactivation of tetanus toxin by crystalline vitamin C (Ι-ascorbic acid). The journ. of Immun. Vol. 33, No. 3, 1937 (Microbiology)
P. R.
Kazan medical journal ›› 1939, Vol. 35 ›› Issue (1) : 119 -119.
Jungeblut, C. W. Inactivation of tetanus toxin by crystalline vitamin C (Ι-ascorbic acid). The journ. of Immun. Vol. 33, No. 3, 1937 (Microbiology)
A number of studies have shown that when 1-ascorbic acid is added to diphtheria toxin, polio virus, encephalitis virus, or tobacco mosaic disease, the toxin or virus is inactivated. Moreover, the “antitoxic” and “antiviral” effect does not depend on the acidic reaction of crystalline vitamin C, since this also occurs when the pH is harmless to the toxin or virus. The mechanism of this phenomenon in vitro has not yet been studied, but there is reason to believe, at least in relation to plant viruses, that inactivation occurs only when reduced ascorbic acid undergoes aerobic oxidation.
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