To the question of splenectomy in essential thrombopenia
M. B. Borisov
Kazan medical journal ›› 1939, Vol. 35 ›› Issue (2-3) : 105 -106.
To the question of splenectomy in essential thrombopenia
Frank first isolated essential thrombopenia as an independent disease from the group of hemorrhagic diatheses in 1915. Katznelson proposed the removal of the spleen in this disease, and the Prague surgeon Schlofer performed the first such procedure in 1916, achieving a notable outcome.
The question of the origin of thrombopenia remains unresolved. All investigators concur that removal of the spleen in thrombopenia yields excellent results. However, some of them posit that the spleen plays a role in cases of thrombopenia by producing a hormone that inhibits the formation of platelets in the bone marrow. Others hypothesize that the origin of thrombopenia is due to the spleen's excessive thrombolytic function. Consequently, there is a myelogenic and splenogenic theory of the origin of thrombopenia.
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