Assessment of cardiovascular risk in women with premature ovarian failure

Abstract

BACKGROUND: Premature ovarian failure is a common disease that affects quality of life and cardiovascular risk in young women.

AIM: To assess the relative risk of cardiovascular events in patients with primary and secondary premature ovarian failure.

MATERIAL AND METHODS: The study included three groups of patients comparable in age: the first — women with primary premature ovarian failure at the age of 39.8±4.3 years; the second — women with secondary premature ovarian failure, age 40.1±4.1 years; the third was the control group at the age of 40.3±3.9 years, there were 133 people in each group. The cardiovascular profile (smoking status, metabolic health, lipid profile, glucose level, blood pressure, pulse and cardiovascular history) of patients with premature ovarian failure was analyzed. Identification of relationships between the studied signs (increase in waist circumference, increase in systolic blood pressure >140 mm Hg, increase in diastolic blood pressure >90 mm Hg, dyslipidemia, arterial hypertension, arrhythmia, coronary heart disease, diabetes mellitus, metabolic syndrome) carried out by calculating the odds ratio and relative risk. The 10-year risk of developing cardiovascular diseases was also calculated using the SCORE2 scale.

RESULTS: Patients with both primary and secondary premature ovarian failure had a higher relative risk of developing cardiovascular events compared with healthy women. The 10-year risk of developing cardiovascular events according to the SCORE2 scale was statistically significantly increased in women with premature ovarian failure compared to the control group. In patients with primary failure it was 9.4% (confidence interval 6–14%; p=0.018), in patients with secondary failure — 7.6% (confidence interval 4–14%; p=0.023), and in the control group — 5.1% (confidence interval 3–14%; p=0.039).

CONCLUSION: Patients with premature ovarian failure have a higher cardiovascular risk compared to a group of healthy women.

Keywords

premature ovarian insufficiency / premature ovarian failure / cardiovascular diseases / hypoestrogenism

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Funding

Исследование выполнено при финансовой поддержке РФФИ в рамках научного проектаThe study was carried out with financial support from the Russian Foundation for Basic Research within the framework of scientific project(20-315-90017)

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