Diagnostic significance of ethanolamine content in blood and urine during nephropathies

Abstract

Aim. To assess the significance of changes in the content of ethanolamine in biological fluids in the diagnosis of nephropathies. Methods. Examined were 246 patients (56% men, 44% women) aged 17 to 68 (41.1±13.1) years and 75 healthy subjects (49% men, 51% women) aged between 16 and 72 (31. 4±12.4) years. The first group consisted of 55 patients with essential hypertension, the second - 47 patients with insulin-dependent diabetes mellitus in the compensation stage, the third - 65 patients suffering from gout. The fourth group included patients with secondary (due to systemic lupus erythematosus - 29 people) and primary chronic glomerulonephritis. We used non-parametric statistical methods: analysis of the differences between the two groups was performed using U-criteria of Mann-Whitney, among three or more groups - the Kruskal-Wallis test; to identify the dependencies - Spearman correlation analysis was used. Results. The content of ethanolamine in the blood correlated poorly with the age, but only in patients with gout (r=-0.3, p=0.03). The concentration of ethanolamine in the blood was significantly lower in the first three groups, in urine was not significantly different from controls only in patients with gout (p=0.05). It is in the first, second and third groups that the majority of patients had a higher body mass index, arterial hypertension and metabolic disorders. There was an inverse relationship between the content of ethanolamine in the blood and the body mass index (r=-0.35, p=0.0001), the concentration of cholesterol in the blood (r=-0.27, p=0.02), weak positive - with creatinine levels (r=0.14, p=0.04). The ANOVA analysis revealed a negative relationship between the concentration of ethanolamine in the blood and body mass index (at f=20.3; p <0.001). Established were significant differences in terms of ethanolamine level in blood and urine when compared to patients with arterial hypertension and without it (p=0.01), as well as when comparing patients with and without dyslipidemia (p=0.02). Conclusion. The decrease in the concentration of ethanolamine in the blood may be a predictor of hemodynamic disturbances in the glomeruli of the kidneys; the content of ethanolamine in the blood is closely related with hypertension and obesity, and in the urine - is not associated with diseases of the diseases of the kidney glomerular apparatus, but correlates with the severity of tubular disorders in gout.

Keywords

nephropathy / renal function tests / ethanolamine / semiology

References

[1] Архипов Е.В., Сигитова О.Н. Роль структурно-функциональной дестабилизации мембран нефроцитов в патогенезе прогрессирования пиелонефрита // Клин. нефрол. - 2010. - №6. - С. 73-76.

[2] Малкоч А.В., Гаврилова В.А. Дисметаболические нефропатии у детей // Леч. врач. - 2001. - №6. - С. 32-36.

[3] Семёнов В.В., Пахалина И.А. Влияние некоторых метаболитов на состояние прооксидантных систем // Неврол. вестн. - 2010. - №2. - С. 50-56.

[4] Халфина Т.Н., Максудова А.Н. Клиническая взаимосвязь артериальной гипертензии и подагры // Клин. нефрол. - 2011. - №6. - С. 42-44.

[5] Chi Y., Gupta R.K. Alterations in heart and kidney membrane phospholipids in hypertension as observed by 31P nuclear magnetic resonance // Lipids. - 1998. - Vol. 33. - P. 1023-1030.

[6] Graessler J., Schwudke D., Schwarz P.E. et al. Top-down lipidomics reveals ether lipid deficiency in blood plasma of hypertensive patients // PLoS One. - 2009. - Vol. 4. - P. 6261.

[7] Lesley A.S., Coresh J., Greene T., Levey A.S. Assessing kidney function - measured and estimated glomerular filtration rate // N. Engl. J. Med. - 2006. - Vol. 354. - P. 2473-2483.

[8] Vance J.E. Molecular and cell biology of phosphatidylserine and phosphatidylethanolamine metabolism // Proq. Nucleic. Acid Res. Mol. Biol. - 2003. - Vol. 75. - P. 69-111.

RIGHTS & PERMISSIONS

Maksudova A.N.