Correction of microcirculation disturbances in the wall of the urinary bladder in women with urination disorders

A I Neymark; M V Razdorskaya; K A Sizov

doi:10.17816/KMJ2148

Kazan medical journal ›› 2012, Vol. 93 ›› Issue (1) : 68 -72. DOI: 10.17816/KMJ2148

Theoretical and clinical medicine

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Correction of microcirculation disturbances in the wall of the urinary bladder in women with urination disorders

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Abstract

Aim. To assess the dynamics of the microcirculation indices in the mucous layer of the urinary bladder on the background of conservative treatment of women with urination disorders. Methods. Examined were 40 women with complaints of urination disorders, who were repeatedly treated regarding this reason. 20 female patients who underwent standard complex conservative therapy represented the first group. The second group included 20 patients who in addition received an α1-adrenergic blocker terazosin in a dose 2 mg at night. The course of treatment ranged from 1 to 3 months. Results. 9 (45%) women of the first group and 16 (80%) patients of the second group observed a positive effect of the treatment. In the patients of the second group registered was a more rapid normalization of clinical signs and indicators of laser Doppler flowmetry: an increase in neurogenic tone in precapillaries, in the bypass index and in the index of effectiveness of microcirculation, an increase in the microcirculation parameter and in the coefficient of variation, which indicates an improvement in the microhemocirculation. Conclusion. The study of blood flow through the capillary vascular bed by laser Doppler flowmetry makes it possible to study the microcirculation in the mucosa of the urinary bladder wall in order to monitor the effectiveness of the conducted therapy.

Keywords

urination disorders / α1-adrenergic blockers / microcirculation / laser Doppler flowmetry

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A I Neymark, M V Razdorskaya, K A Sizov. Correction of microcirculation disturbances in the wall of the urinary bladder in women with urination disorders. Kazan medical journal, 2012, 93(1): 68-72 DOI:10.17816/KMJ2148

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