Dynamics of the content of biologically active substances in peripheral blood neutrophils in patients with ischemic heart disease during the course of laser therapy

Abstract

Aim. To study the dynamics of the content of catecholamines, serotonin, histamine and heparin in peripheral blood neutrophils of patients with ischemic heart disease under the influence of laser therapy. Methods. Examined were 124 patients with angina, who were divided into two groups: those receiving basic treatment (β-blockers, antiplatelet drugs, nitrates, statins) with a course of laser therapy - 76 people, and those receiving only basic treatment - 48 people. The control group included 32 healthy individuals. Results. In patients with angina the content of catecholamines, serotonin, histamine is higher, while the content of heparin is lower than in healthy individuals. Under the influence of laser therapy, which was conducted simultaneously with the basic treatment, a decrease occurred in the level of catecholamines by 1.6 times, of serotonin by 1.5 times, of histamine by 1.6 times and an increase occurred in the amount of heparin by 1.9 times. Conclusion. Laser therapy effects the contents of all studied biologically active substances, bringing them closer to those of healthy people.

Keywords

laser therapy / angina / catecholamines / heparin / histamine / serotonin

References

[1] Чазов Е.И. Руководство по внутренним болезням. Болезни органов кровообращения / Е.И. Чазов - М.: Медицина, 1997. - С. 663-685.

[2] Côte F., Fligny C., Fromes Y. et al. Recent advances in understanding serotonin regulation of cardiovascular function // Trends Mol. Med. - 2004. - Vol. 10. - P. 232-238.

RIGHTS & PERMISSIONS

Sapozhnikov M.Y.