The influence of diabetes mellitus on blood lipid profile in patients with coronary vessel restenosis associated with Helicobacter pylori

Abstract

Aim. To determine the influence of diabetes mellitus on the level of blood lipid profile in patients with coronary restenosis associated with H. pylori.

Methods. The study included 50 patients with coronary artery disease and coronary restenosis associated with H. pylori infection. Patients were divided into 2 groups: with concomitant diabetes mellitus (group 1, n=10 patients) and without it (group 2, n=40). The groups were comparable by age, sex, and clinical and angiographic data. All patients along with basic therapy additionally received standard first-line anti-helicobacter therapy in accordance with the Maastricht Consensus-3 (2005) for 14 days. Before treatment and 90 days after treatment, blood lipid profile was evaluated with Siemens Dimension X pand plus device. To analyze the obtained digital data, the arithmetic mean of the indicator (M) and the error of the mean (m) were calculated. The statistical significance of the difference between the groups was determined by Pearson χ2 test. Differences were considered significant at p <0.05. Statistical data processing was performed using the SPSS statistical package and the Excel-2013.

Results. A comparative analysis of qualitative indicators showed that in both groups in most cases (90 and 87.5%, respectively), the level of low density lipids was above the norm, but they did not differ between the groups (χ2=0.047; р=0.828). After eradication in both groups, both qualitative (60 and 67.5% respectively) and quantitative values of low density lipids improved significantly (decreased to 98.2±8.6 and 97.6±7.9 mg/dl, respectively) however, no significant differences between the groups were found (p ˃0.05).

Conclusion. A history of diabetes mellitus in patients with coronary restenosis associated with H. pylori cannot be considered as an additional factor that increases the likelihood of developing the disorders of lipid profile; successful eradication therapy in this category of patients contributes to the normalization of lipid profile regardless of the presence or absence of concomitant diabetes mellitus.

Keywords

Helicobacter pylori / ischemic heart disease / restenosis / eradication / blood lipid profile

RIGHTS & PERMISSIONS

Gadzhieva S.Z.