Evaluation of the impact of specific preventive measures on the incidence of tick-borne viral encephalitis in the Altai Krai in 2000-2017

Abstract

Aim. Analysis of the effectiveness of specific preventive measures against tick-borne viral encephalitis among the urban and rural population of the Altai Krai of different age groups in 2000-2017.

Methods. The paper presents the results of a long-term epidemiological analysis of the incidence among urban and rural population of the Altai Krai of tick-borne viral encephalitis in 2000-2017, the calculation of absolute and relative indicators, long-standing dynamics of the incidence of tick-borne viral encephalitis in RF ad Altai Krai was evaluzted as well as summarized parameter of vaccination and revaccination. Statistical data processing was carried out in the program Statistica 12.0.

Results. The study revealed an inverse moderate correlation between the factor of the volume of emergency prophylaxis and the incidence of tick-borne viral encephalitis among the population of the Altai Krai (r=-0.51; p <0.001), between these phenomena in the cohort of adult population of the region (r=-0.50; p <0.001), in the cohort of children in the region (r=-0.52; p <0.001), in the cohort of urban residents (r=-0.54; p <0.001), in the cohort of rural residents (r=-0,45; p <0.001). The causes of differences in the incidence of tick-borne viral encephalitis among the urban and rural population of the Altai Krai were identified, the degree of relation between the average long-term incidence rates and its determining factors were determined, recommendations were developed to optimize the system of preventive measures of tick-borne encephalitis in the region.

Conclusion. The absence of a negative correlation in the various cohorts of the population between the incidence and vaccination levels indicates a lack of effectiveness of vaccination against tick-borne viral encephalitis in the region; at the same time, the inverse moderate correlation revealed between the incidence of tick-borne viral encephalitis and the indicators of emergency immunoprophylaxis indicates a sufficient degree of effectiveness of this specific preventive measure in the Altai Krai.

Keywords

tick-borne encephalitis / vaccination / immunoglobulin / specific prophylaxis / Altai Krai

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RIGHTS & PERMISSIONS

Saldan I.P., Timonin A.V., Shirokostup S.V., Luk’yanenko N.V., Balandovich B.A.