Current views on the possibility of cervical insufficiency correction
O V Yakovleva , T N Glukhova , I E Rogozhina
Kazan medical journal ›› 2019, Vol. 100 ›› Issue (2) : 264 -269.
Current views on the possibility of cervical insufficiency correction
The main role in spontaneous abortion in 2nd and 3d trimesters is assigned to cervical insufficiency. According to a number of researchers, bed rest, elevated lower limbs, restriction of physical activity, tocolysis, antibacterial therapy do not affect the prolongation of pregnancy and are ineffective for preventing premature spontaneous labor. Correction of cervical insufficiency can be carried out by a vaginal form of progesterone, cerclage, pessary. The use of vaginal progesterone is justified in women with recurrent miscarriage, a history of premature birth, and shortening of the cervix to less than 25 mm. Indications for surgical correction are limited to patients with habitual loss of pregnancy due to cervical weakness or a history of premature birth. In the absence of significant obstetric history, cerclage has no advantages over the use of progesterone. The optimal time for cerclage is up to 20 weeks of pregnancy. Unlike progesterone cerclage has complications, the frequency and severity of which are attributable to the timing and indications for correction. Transabdominal cerclage is performed only when there is a technical impossibility of vaginal access due to the absence of a vaginal part of the cervix or after unsuccessful attempts of vaginal cerclages. Most often, the use of a pessary is associated with the diagnosis of a short cervix in terms of more than 24 weeks of gestation in the absence of an aggravated history. The combined use of gestagens, pessary and cerclage does not increase the efficiency of carrying a singleton pregnancy. Methods for the prevention of preterm delivery in multiple pregnancy, such as the introduction of a specialized outpatient service, bed rest, antibacterial therapy, progesterone, preventive cerclage or the insertion of a pessary do not change the incidence and mortality of newborns.
progestogen / cerclage / obstetric pessary
| [1] |
Blencowe H., Cousens S., Chou D. et al. Born too soon: the global epidemiology of 15 million preterm births. Reprod. Health. 2013; 10 (1): S2. DOI: 10.1186/1742-4755-10-S1-S2. |
| [2] |
Delnord M., Blondel B., Zeitlin J. What contributes to disparities in the preterm birth rate in European countries? Curr. Opin. Obstet. Gynecol. 2015; 27 (2): 133–142. DOI: 10.1097/GCO.0000000000000156. |
| [3] |
Delnord M., Blondel B., Zeitlin J. What contributes to disparities in the preterm birth rate in European countries? Curr. Opin. Obstet. Gynecol. 2015; 27 (2): 133-142. DOI: 10.1097/GCO.0000000000000156. |
| [4] |
Romero R., Yeo L., Miranda J. et al. A blueprint for the prevention of preterm birth: vaginal progesterone in women with a short cervix. J. Perinatal. Med. 2013; 41 (1): 27–44. DOI: 10.1515/jpm-2012-0272. |
| [5] |
Romero R., Yeo L., Miranda J. et al. A blueprint for the prevention of preterm birth: vaginal progesterone in women with a short cervix. J. Perinatal. Med. 2013; 41 (1): 27-44. DOI: 10.1515/jpm-2012-0272. |
| [6] |
Yorifuji T., Makino S., Yamamoto Y. et al. Effectiveness of delayed absorbable monofilament suture in emergency cerclage. Taiwanese J. Obstet. Gynecol. 2014; 53 (3): 382–384. DOI: 10.1155/2018/4049792. |
| [7] |
Yorifuji T., Makino S., Yamamoto Y. et al. Effectiveness of delayed absorbable monofilament suture in emergency cerclage. Taiwanese J. Obstet. Gynecol. 2014; 53 (3): 382-384. DOI: 10.1155/2018/4049792. |
| [8] |
American College of Obstetricians and Gynecologists. Cerclage for the management of cervical insufficiency. Obstet. Gynecol. 2014; 123 (2): 372–379. DOI: 10.1097/01.AOG.0000443276.68274.cc. |
| [9] |
American College of Obstetricians and Gynecologists. Cerclage for the management of cervical insufficiency. Obstet. Gynecol. 2014; 123 (2): 372-379. DOI: 10.1097/01.AOG.0000443276.68274.cc. |
| [10] |
Romero R., Conde-Agudelo A., El-Refaie W. et al. Vaginal progesterone decreases preterm birth and neonatal morbidity and mortality in women with a twin gestation and a short cervix: an updated meta-analysis of individual patient data. Ultrasound Obstet. Gynecol. 2017; 49 (3): 303–314. DOI: 10.1002/uog.17397. |
| [11] |
Romero R., Conde-Agudelo A., El-Refaie W. et al. Vaginal progesterone decreases preterm birth and neonatal morbidity and mortality in women with a twin gestation and a short cervix: an updated meta-analysis of individual patient data. Ultrasound Obstet. Gynecol. 2017; 49 (3): 303-314. DOI: 10.1002/uog.17397. |
| [12] |
Conde-Agudelo A., Romero R., Da Fonseca E. et al. Vaginal progesterone is as effective as cervical cerclage to prevent preterm birth in women with a singleton gestation, previous spontaneous preterm birth, and a short cervix: updated indirect comparison meta-analysis. Am. J. Obstet. Gynecol. 2018; 219 (1): 10–25. DOI: 10.1016/j.ajog.2018.03.028. |
| [13] |
Conde-Agudelo A., Romero R., Da Fonseca E. et al. Vaginal progesterone is as effective as cervical cerclage to prevent preterm birth in women with a singleton gestation, previous spontaneous preterm birth, and a short cervix: updated indirect comparison meta-analysis. Am. J. Obstet. Gynecol. 2018; 219 (1): 10-25. DOI: 10.1016/j.ajog.2018.03.028. |
| [14] |
Dodd J.M., Grivell R.M., Brien C.M. et al. Prenatal administration of progestogens for preventing spontaneous preterm birth in women with a multiple pregnancy. Cochrane Database Syst. Rev. 2017; 10: CD012024. DOI: 10.1002/14651858.CD012024.pub2. |
| [15] |
Canadian Agency for Drugs and Technologies in Health. Vaginal micronized progesterone capsules for the prevention of miscarriage and preterm birth: a review of the clinical evidence. 2014; 28. https://www.cadth.ca/vaginal-micronized-progesterone-capsules-prevention-mis |
| [16] |
Canadian Agency for Drugs and Technologies in Health. Vaginal micronized progesterone capsules for the prevention of miscarriage and preterm birth: a review of the clinical evidence. 2014; 28. https://www.cadth.ca/vaginal-micronized-progesterone-capsules-prevention-mis carriage-and-preterm-birth-review-clinical (access date: 09.12.2018). |
| [17] |
carriage-and-preterm-birth-review-clinical (access date: 09.12.2018). |
| [18] |
National Collaborating Centre for Women's and Children's Health. Preterm labour and birth. London (UK): National Institute for Health and Care Excellence (NICE). 2015; 20: 24. https://www.nice.org.uk/guidance/ng25/doc uments/preterm-labour-and-birth-appendices-a-g2 (access date: 09.12.2018). |
| [19] |
National Collaborating Centre for Women's and Children's Health. Preterm labour and birth. London (UK): National Institute for Health and Care Excellence (NICE). 2015; 20: 24. https://www.nice.org.uk/guidance/ng25/doc |
| [20] |
Norman J.E., Marlow N., Messow C. et al. Vaginal progesterone prophylaxis for preterm birth (the OPPTIMUM study): a multicentre, randomised, double-blind trial. Lancet. 2016; 387: 2106-2116. DOI: 10.1016/S0140- 6736(16)00350-0. |
| [21] |
uments/preterm-labour-and-birth-appendices-a-g2 (access date: 09.12.2018). |
| [22] |
El-refaie W., Abdelhafez M.S., Badawy A. Vaginal progesterone for prevention of preterm labor in asymptomatic twin pregnancies with sonographic short cervix: a randomized clinical trial of efficacy and safety. Arch. Gynecol. Obstet. 2016; 293 (1): 61-67. DOI: 10.1007/s00404-015-3767-1. |
| [23] |
Norman J.E., Marlow N., Messow C. et al. Vaginal progesterone prophylaxis for preterm birth (the OPPTIMUM study): a multicentre, randomised, double-blind trial. Lancet. 2016; 387: 2106–2116. DOI: 10.1016/S0140- |
| [24] |
Dodd J.M., Grivell R.M., Obrien C.M. et al. Prenatal administration of progestogens for preventing spontaneous preterm birth in women with a multiple pregnancy. Cochrane Database of Syst. Rev. 2017; 10: CD012024. DOI: 10.1002/14651858.CD012024.pub2. |
| [25] |
6736(16)00350-0. |
| [26] |
Pustotina O. Effectiveness of dydrogesterone, 17-OH progesterone and micronized progesterone in prevention of preterm birth in women with a short cervix. J. Matern. Fetal. Neonatal. Med. 2018; 31 (14)6 1830-1838. DOI: 10.1080/14767058.2017.1330406. |
| [27] |
El-refaie W., Abdelhafez M.S., Badawy A. Vaginal progesterone for prevention of preterm labor in asymptomatic twin pregnancies with sonographic short cervix: a randomized clinical trial of efficacy and safety. Arch. Gynecol. Obstet. 2016; 293 (1): 61–67. DOI: 10.1007/s00404-015-3767-1. |
| [28] |
Eleje G.U., Ikechebelu J.I., Ahizechukwu C.E. et al. Cervical cerclage in combination with other treatments for preventing preterm birth in singleton pregnancies. Cochrane Database of Syst. Rev. 2017; 11. DOI: 10.1002/14651858.cd012871. |
| [29] |
Dodd J.M., Grivell R.M., Obrien C.M. et al. Prenatal administration of progestogens for preventing spontaneous preterm birth in women with a multiple pregnancy. Cochrane Database of Syst. Rev. 2017; 10: CD012024. DOI: 10.1002/14651858.CD012024.pub2. |
| [30] |
Alfirevic Z., Stampalija T., Medley N. Cervical stitch (cerclage) for preventing preterm birth in singleton pregnancy. Cochrane Database of Syst. Rev. 2017; 6. DOI: 10.1002/14651858.CD008991.pub3. |
| [31] |
Pustotina O. Effectiveness of dydrogesterone, 17-OH progesterone and micronized progesterone in prevention of preterm birth in women with a short cervix. J. Matern. Fetal. Neonatal. Med. 2018; 31 (14)6 1830–1838. DOI: 10.1080/14767058.2017.1330406. |
| [32] |
Simonazzi G., Curti A., Bisulli M. et al. Cervical lacerations in planned versus labor cerclage removal: a systematic review. Eur. J. Obstet. Gynecol. Reprod. Biol. 2015; 193: 19-22. DOI: 10.1016/j.ejogrb.2015.06.032. |
| [33] |
Eleje G.U., Ikechebelu J.I., Ahizechukwu C.E. et al. Cervical cerclage in combination with other treatments for preventing preterm birth in singleton pregnancies. Cochrane Database of Syst. Rev. 2017; 11. DOI: 10.1002/14651858.cd012871. |
| [34] |
Sato Y., Hidaka N., Nakano T. et al. Efficacy of an emergency cervical cerclage using absorbable monofilament sutures. J. Pregnancy. 2018; 4049792: 5. DOI: 10.1155/2018/4049792. |
| [35] |
Alfirevic Z., Stampalija T., Medley N. Cervical stitch (cerclage) for preventing preterm birth in singleton pregnancy. Cochrane Database of Syst. Rev. 2017; 6. DOI: 10.1002/14651858.CD008991.pub3. |
| [36] |
Neveu M.E., Fernandez H., Deffieux X. et al. Fertility and pregnancy outcomes after transvaginal cervico-isthmic cerclage. Eur. J. Obstet. Gynecol. Reprod. Biol. 2017; 218: 21-26. DOI: 10.1016/j.ejogrb.2017.09.007. |
| [37] |
Simonazzi G., Curti A., Bisulli M. et al. Cervical lacerations in planned versus labor cerclage removal: a systematic review. Eur. J. Obstet. Gynecol. Reprod. Biol. 2015; 193: 19–22. DOI: 10.1016/j.ejogrb.2015.06.032. |
| [38] |
Brown R., Gagnon R., Delisle M.F. et al. Cervical insufficiency and cervical cerclage. J. Obstet. Gynaecol. Can. 2013; 35 (12): 1115-1127. DOI: 10.1016/S1701-2163(15)30764-7. |
| [39] |
Sato Y., Hidaka N., Nakano T. et al. Efficacy of an emergency cervical cerclage using absorbable monofilament sutures. J. Pregnancy. 2018; 4049792: 5. DOI: 10.1155/2018/4049792. |
| [40] |
Anon. ACOG. Practice Bulletin No. 142. Cerclage for the management of cervical insufficiency. Obstet. Gynecol. 2014; 123 (2, Pt. 1): 372-379. DOI: 10.1097/01.AOG.0000443276.68274.cc. |
| [41] |
Neveu M.E., Fernandez H., Deffieux X. et al. Fertility and pregnancy outcomes after transvaginal cervico-isthmic cerclage. Eur. J. Obstet. Gynecol. Reprod. Biol. 2017; 218: 21–26. DOI: 10.1016/j.ejogrb.2017.09.007. |
| [42] |
Berghella V., Ciardulli A., Rust O.A. et al. Cerclage for sonographic short cervix in singleton gestations without prior spontaneous preterm birth: systematic review and meta-analysis of randomized controlled trials using individual patient-level data. Ultrasound. Obstet. Gynecol. 2017; 50: 569-577. DOI: 10.1002/uog.17457. |
| [43] |
Brown R., Gagnon R., Delisle M.F. et al. Cervical insufficiency and cervical cerclage. J. Obstet. Gynaecol. Can. 2013; 35 (12): 1115–1127. DOI: 10.1016/S1701-2163(15)30764-7. |
| [44] |
Kindinger L.M., Kyrgiou M., MacIntyre D.A. et al. Preterm birth prevention post-conization: a model of cervical length screening with targeted cerclage. PLoS One. 2016; 11 (11): е0163793. DOI: 10.1371/journal.pone.0163793. |
| [45] |
Anon. ACOG. Practice Bulletin No. 142. Cerclage for the management of cervical insufficiency. Obstet. Gynecol. 2014; 123 (2, Pt. 1): 372–379. DOI: 10.1097/01.AOG.0000443276.68274.cc. |
| [46] |
Marcellin L. Prevention of preterm birth by uterine cervical cerclage. J. Gynecol. Obstet. Biol. Reprod. (Paris). 2016; 45 (10): 1299-1323. DOI: 10.1016/j.jgyn.2016.09.022. |
| [47] |
Berghella V., Ciardulli A., Rust O.A. et al. Cerclage for sonographic short cervix in singleton gestations without prior spontaneous preterm birth: systematic review and meta-analysis of randomized controlled trials using individual patient-level data. Ultrasound. Obstet. Gynecol. 2017; 50: 569–577. DOI: 10.1002/uog.17457. |
| [48] |
Auber M., Hamou L., Roman H. et al. Transabdominal cervico-isthmic cerclage: 13 cases at Rouen University Hospital. Gynecol. Obstet. Fertil. 2012; 40 (12): 741-745. DOI: 10.1016/j.gyobfe.2011.07.036. |
| [49] |
Kindinger L.M., Kyrgiou M., MacIntyre D.A. et al. Preterm birth prevention post-conization: a model of cervical length screening with targeted cerclage. PLoS One. 2016; 11 (11): е0163793. DOI: 10.1371/journal.pone.0163793. |
| [50] |
Huras H., Kalinka J., Dębski R. Short cervix in twin pregnancies: current state of knowledge and the proposed scheme of treatment. Ginekol. Pol. 2017; 88 (11): 626-632. DOI: 10.5603/GP.a2017.0112. |
| [51] |
Marcellin L. Prevention of preterm birth by uterine cervical cerclage. J. Gynecol. Obstet. Biol. Reprod. (Paris). 2016; 45 (10): 1299–1323. DOI: 10.1016/j.jgyn.2016.09.022. |
| [52] |
Hita M.M., Paniza L.R., Durán S.R. Pessary cervical and prevention preterm birth based on literature review. Int. J. Pregn. Chi. Birth. 2018; 4 (4): 188-193. DOI: 10.15406/ipcb.2018.04.00108. |
| [53] |
Auber M., Hamou L., Roman H. et al. Transabdominal cervico-isthmic cerclage: 13 cases at Rouen University Hospital. Gynecol. Obstet. Fertil. 2012; 40 (12): 741–745. DOI: 10.1016/j.gyobfe.2011.07.036. |
| [54] |
Falcao V., Melo C., Matias A. et al. Cervical pessary for the prevention of preterm birth: is it of any use? J. Perinatal. Med. 2016; 45 (1): 21-27. DOI: 10.1515/jpm-2016-0076. |
| [55] |
Huras H., Kalinka J., Dębski R. Short cervix in twin pregnancies: current state of knowledge and the proposed scheme of treatment. Ginekol. Pol. 2017; 88 (11): 626–632. DOI: 10.5603/GP.a2017.0112. |
| [56] |
Saccone G., Maruotti G.M., Giudicepietro A. et al. Effect of cervical pessary on spontaneous preterm birth in women with singleton pregnancies and short cervical length: a randomized clinical trial. JAMA. 2017; 318 (23): 2317-2324. DOI: 10.1001/jama.2017.18956. |
| [57] |
Hita M.M., Paniza L.R., Durán S.R. Pessary cervical and prevention preterm birth based on literature review. Int. J. Pregn. Chi. Birth. 2018; 4 (4): 188‒193. DOI: 10.15406/ipcb.2018.04.00108. |
| [58] |
Saccone G., Ciardulli A., Xodo S. et al. Cervical pessary for preventing preterm birth in twin pregnancies with short cervical length: a systematic review and meta-analysis. J. Matern. Fetal. Neonatal. Med. 2017; 30 (24): 2918-2925. DOI: 10.1080/14767058.2016.1268595. |
| [59] |
Falcao V., Melo C., Matias A. et al. Cervical pessary for the prevention of preterm birth: is it of any use? J. Perinatal. Med. 2016; 45 (1): 21–27. DOI: 10.1515/jpm-2016-0076. |
| [60] |
American College of Obstetricians and Gynecologists (ACOG). Multifetal gestations: twin, triplet, and higher-order multifetal pregnancies. Washington (DC): American College of Obstetricians and Gynecologists (ACOG). 2014; 15. https://www.acog.org/Clinical-Guid ance-and-Publications/Committee-Opinions/Committee-on-Ethics/Multifetal-Pregnancy-Reduction (access date: 01.12.2018). |
| [61] |
Saccone G., Maruotti G.M., Giudicepietro A. et al. Effect of cervical pessary on spontaneous preterm birth in women with singleton pregnancies and short cervical length: a randomized clinical trial. JAMA. 2017; 318 (23): 2317–2324. DOI: 10.1001/jama.2017.18956. |
| [62] |
Dodd J.M., Dowswell T., Crowther C.A. Specialised antenatal clinics for women with a multiple pregnancy for improving maternal and infant outcomes. Cochrane Database of Syst. Rev. 2015. DOI: 10.1002/14651858.CD00 5300.pub4. |
| [63] |
Saccone G., Ciardulli A., Xodo S. et al. Cervical pessary for preventing preterm birth in twin pregnancies with short cervical length: a systematic review and meta-analysis. J. Matern. Fetal. Neonatal. Med. 2017; 30 (24): 2918–2925. DOI: 10.1080/14767058.2016.1268595. |
| [64] |
Zimerman A., Maymon R., Viner Y. et al. Prevention of preterm birth in twins with short mid-trimester cervical length less than 25 mm - combined treatment with arabin's cerclage pessary and intravaginal micronized progesterone compared with conservative treatment. Harefuah. 2018; 157 (5): 301-304. PMID: 29804334. |
| [65] |
American College of Obstetricians and Gynecologists (ACOG). Multifetal gestations: twin, triplet, and higher-order multifetal pregnancies. Washington (DC): American College of Obstetricians and Gynecologists (ACOG). 2014; 15. https://www.acog.org/Clinical-Guid |
| [66] |
Fox N.S., Gupta S., Lam-Rachlin J. et al. Cervical Pessary and vaginal progesterone in twin pregnancies with a short cervix. Obstet. Gynecol. 2016; 127 (4): 625-630. DOI: 10.1097/AOG.0000000000001300. |
| [67] |
ance-and-Publications/Committee-Opinions/Committee-on-Ethics/Multifetal-Pregnancy-Reduction (access date: 01.12.2018). |
| [68] |
Jarde A., Lewis-Mikhael A.M., Dodd J.M. et al. The more, the better? Combining interventions to prevent preterm birth in women at risk: a systematic review and meta-analysis. J. Obstet. Gynaecol. Can. 2017; 39 (12): 1192-1202. DOI: 10.1016/j.jogc.2017.07.007. |
| [69] |
Dodd J.M., Dowswell T., Crowther C.A. Specialised antenatal clinics for women with a multiple pregnancy for improving maternal and infant outcomes. Cochrane Database of Syst. Rev. 2015. DOI: 10.1002/14651858.CD005300.pub4. |
| [70] |
Zimerman A., Maymon R., Viner Y. et al. Prevention of preterm birth in twins with short mid-trimester cervical length less than 25 mm — combined treatment with arabin's cerclage pessary and intravaginal micronized progesterone compared with conservative treatment. Harefuah. 2018; 157 (5): 301–304. PMID: 29804334. 34. Fox N.S., Gupta S., Lam-Rachlin J. et al. Cervical Pessary and vaginal progesterone in twin pregnancies with a short cervix. Obstet. Gynecol. 2016; 127 (4): 625–630. DOI: 10.1097/AOG.0000000000001300. |
| [71] |
Jarde A., Lewis-Mikhael A.M., Dodd J.M. et al. The more, the better? Combining interventions to prevent preterm birth in women at risk: a systematic review and meta-analysis. J. Obstet. Gynaecol. Can. 2017; 39 (12): 1192–1202. DOI: 10.1016/j.jogc.2017.07.007. |
Yakovleva O.V., Glukhova T.N., Rogozhina I.E.
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